Nicholas J Barrows
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Explore the profile of Nicholas J Barrows including associated specialties, affiliations and a list of published articles.
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11
Citations
936
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Recent Articles
1.
Quarato G, Mari L, Barrows N, Yang M, Ruehl S, Chen M, et al.
Sci Adv
. 2023 May;
9(21):eadg8156.
PMID: 37224250
Degradation of defective mitochondria is an essential process to maintain cellular homeostasis and it is strictly regulated by the ubiquitin-proteasome system (UPS) and lysosomal activities. Here, using genome-wide CRISPR and...
2.
Kim B, Arcos S, Rothamel K, Jian J, L Rose K, McDonald W, et al.
Mol Cell
. 2020 May;
78(4):624-640.e7.
PMID: 32380061
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viral...
3.
Barrows N, Anglero-Rodriguez Y, Kim B, Jamison S, Le Sommer C, McGee C, et al.
Sci Rep
. 2019 Jul;
9(1):9711.
PMID: 31273220
Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient...
4.
Barrows N, Campos R, Liao K, Prasanth K, Soto-Acosta R, Yeh S, et al.
Chem Rev
. 2018 Apr;
118(8):4448-4482.
PMID: 29652486
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year....
5.
Barrows N, Campos R, Powell S, Prasanth K, Schott-Lerner G, Soto-Acosta R, et al.
Cell Host Microbe
. 2016 Aug;
20(2):259-70.
PMID: 27476412
Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus (ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block infection...
6.
Bogerd H, Skalsky R, Kennedy E, Furuse Y, Whisnant A, Flores O, et al.
J Virol
. 2014 May;
88(14):8065-76.
PMID: 24807715
The issue of whether viruses are subject to restriction by endogenous microRNAs (miRNAs) and/or by virus-induced small interfering RNAs (siRNAs) in infected human somatic cells has been controversial. Here, we...
7.
Barrows N, Jamison S, Bradrick S, Le Sommer C, Kim S, Pearson J, et al.
Methods Mol Biol
. 2014 Apr;
1138:285-99.
PMID: 24696344
Dengue virus (DENV) is endemic throughout tropical regions of the world and there are no approved treatments or anti-transmission agents currently available. Consequently, there exists an enormous unmet need to...
8.
Le Sommer C, Barrows N, Bradrick S, Pearson J, Garcia-Blanco M
PLoS Negl Trop Dis
. 2012 Oct;
6(9):e1820.
PMID: 23029581
Flaviviruses cause a wide range of severe diseases ranging from encephalitis to hemorrhagic fever. Discovery of host factors that regulate the fate of flaviviruses in infected cells could provide insight...
9.
Panda D, Das A, Dinh P, Subramaniam S, Nayak D, Barrows N, et al.
Proc Natl Acad Sci U S A
. 2011 Nov;
108(47):19036-41.
PMID: 22065774
Negative-strand (NS) RNA viruses comprise many pathogens that cause serious diseases in humans and animals. Despite their clinical importance, little is known about the host factors required for their infection....
10.
Barrows N, Le Sommer C, Garcia-Blanco M, Pearson J
J Biomol Screen
. 2010 Jul;
15(7):735-47.
PMID: 20625183
RNA interference-based screening is a powerful new genomic technology that addresses gene function en masse. To evaluate factors influencing hit list composition and reproducibility, the authors performed 2 identically designed...