Nicholas I Fleming
Overview
Explore the profile of Nicholas I Fleming including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
6
Citations
356
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Slatter T, Wilson M, Tang C, Campbell H, Ward V, Young V, et al.
Oncoimmunology
. 2016 May;
5(3):e1112941.
PMID: 27141366
Activated antigen-presenting cells (APC) deliver the three signals cytotoxic T cells require to differentiate into effector cells that destroy the tumor. These comprise antigen, co-stimulatory signals and cytokines. Once these...
2.
Diesch J, Sanij E, Gilan O, Love C, Tran H, Fleming N, et al.
PLoS One
. 2014 Mar;
9(3):e88950.
PMID: 24658684
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown...
3.
Fleming N, Jorissen R, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, et al.
Cancer Res
. 2012 Nov;
73(2):725-35.
PMID: 23139211
Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations in the pathway members TGFBR2 and SMAD4,...
4.
Sakthianandeswaren A, Christie M, Dandreti C, Tsui C, Jorissen R, Li S, et al.
Cancer Res
. 2011 May;
71(10):3709-19.
PMID: 21558389
Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial stem cells. Equivalent cell populations are thought to exist in the human...
5.
Fleming N, Knower K, Lazarus K, Fuller P, Simpson E, Clyne C
PLoS One
. 2010 Dec;
5(12):e14389.
PMID: 21188138
Background: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2...
6.
Fleming N, Trivett M, George J, Slavin J, Murray W, Moseley J, et al.
Cancer Res
. 2009 Sep;
69(18):7473-9.
PMID: 19723659
Parathyroid hormone-related protein (PTHrP) is required for mammary gland development and promotes the growth of breast cancer metastases within bone. However, there are conflicting reports of the prognostic significance of...