Nicholas Dopkins
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Explore the profile of Nicholas Dopkins including associated specialties, affiliations and a list of published articles.
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21
Citations
231
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Recent Articles
1.
Michael S, Liotta N, Fei T, Bendall M, Nixon D, Dopkins N
Microbes Infect
. 2024 Dec;
105465.
PMID: 39681187
Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by impairment of the CF transmembrane conductance regulator (CFTR) via gene mutation. CFTR is expressed at the cellular membrane of...
2.
Mitchell C, Staley S, Williams M, Saxena A, Bogdon R, Roark K, et al.
Front Immunol
. 2024 Sep;
15:1444045.
PMID: 39229279
Introduction: Colitis is an inflammatory bowel disease (IBD) characterized by immune cell dysregulation and alterations in the gut microbiome. In our previous report, we showed a natural product in cruciferous...
3.
Ndhlovu L, Bendall M, Dwaraka V, Pang A, Dopkins N, Carreras N, et al.
Aging Cell
. 2024 Aug;
23(10):e14288.
PMID: 39092674
Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that...
4.
Dopkins N, Fei T, Michael S, Liotta N, Guo K, Mickens K, et al.
EBioMedicine
. 2024 Apr;
103:105133.
PMID: 38677181
Background: Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the...
5.
Reyes-Gopar H, Marston J, Singh B, Greenig M, Lin J, Ostrowski M, et al.
bioRxiv
. 2024 Jan;
PMID: 38234829
Single cell RNA sequencing (scRNA-seq) is revolutionizing the study of complex biological systems. However, most sequencing studies overlook the contribution of transposable element (TE) expression to the transcriptome. In both...
6.
Dopkins N, Singh B, Michael S, Zhang P, Marston J, Fei T, et al.
BMC Genomics
. 2024 Jan;
25(1):5.
PMID: 38166631
Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily...
7.
Martinez-Meza S, Singh B, Nixon D, Dopkins N, Gangcuangco L
Bioelectron Med
. 2023 Dec;
9(1):29.
PMID: 38115148
Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in the body, and partially innervates hepatic functionality...
8.
Ndhlovu L, Bendall M, Dwaraka V, Pang A, Dopkins N, Carreras N, et al.
bioRxiv
. 2023 Dec;
PMID: 38106164
Human endogenous retroviruses (HERVs), the remnants of ancient viral infections embedded within the human genome, and long interspersed nuclear elements 1 (LINE-1), a class of autonomous retrotransposons, are silenced by...
9.
Dopkins N, Nixon D
Nat Rev Mol Cell Biol
. 2023 Oct;
25(3):212-222.
PMID: 37872387
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient retroviral infections. These sequences became fixed and accumulate mutations or deletions over time....
10.
Singh B, Dopkins N, Fei T, Marston J, Michael S, Reyes-Gopar H, et al.
bioRxiv
. 2023 Jun;
PMID: 37333202
The heterogeneity of cancers are driven by diverse mechanisms underlying oncogenesis such as differential 'cell-of-origin' (COO) progenitors, mutagenesis, and viral infections. Classification of B-cell lymphomas have been defined by considering...