Nicholas Boddicker
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Explore the profile of Nicholas Boddicker including associated specialties, affiliations and a list of published articles.
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9
Citations
105
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Recent Articles
1.
Huang H, Hu C, Na J, Hart S, Gnanaolivu R, Abozaid M, et al.
Nature
. 2025 Jan;
638(8050):528-537.
PMID: 39779857
Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers. However, variants of uncertain significance limit the clinical utility of test results. Thus,...
2.
Yiangou K, Mavaddat N, Dennis J, Zanti M, Wang Q, Bolla M, et al.
Breast Cancer Res
. 2024 Dec;
26(1):189.
PMID: 39734228
Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk...
3.
Huang H, Couch R, Karam R, Hu C, Boddicker N, Polley E, et al.
Clin Cancer Res
. 2024 Nov;
31(1):130-138.
PMID: 39513960
Purpose: To determine the relationship between germline pathogenic variants (PV) in cancer predisposition genes and the risk of ductal carcinoma in situ (DCIS). Experimental Design: Germline PV frequencies in breast...
4.
Yiangou K, Mavaddat N, Dennis J, Zanti M, Wang Q, Bolla M, et al.
medRxiv
. 2024 Feb;
PMID: 38410445
The 313-variant polygenic risk score (PRS) provides a promising tool for breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has...
5.
Huang H, Hu C, Na J, Hart S, Gnanaolivu R, Abozaid M, et al.
bioRxiv
. 2024 Jan;
PMID: 38168194
Summary: Germline BRCA2 loss-of function (LOF) variants identified by clinical genetic testing predispose to several types of cancer. However, variants of uncertain significance (VUS) limit the clinical use of testing...
6.
Stolarova L, Kleiblova P, Zemankova P, Stastna B, Janatova M, Soukupova J, et al.
Clin Cancer Res
. 2023 Jul;
29(16):3037-3050.
PMID: 37449874
Purpose: Germline pathogenic variants in CHEK2 confer moderately elevated breast cancer risk (odds ratio, OR ∼ 2.5), qualifying carriers for enhanced breast cancer screening. Besides pathogenic variants, dozens of missense...
7.
Hu C, Nagaraj A, Shimelis H, Montalban G, Lee K, Huang H, et al.
Cancer Res
. 2023 May;
83(15):2557-2571.
PMID: 37253112
Significance: Functional analysis of the impact of a large number of missense variants on RAD51C function provides insight into RAD51C activity and information for classification of the cancer relevance of...
8.
Yadav S, Hu C, Hart S, Boddicker N, Polley E, Na J, et al.
J Clin Oncol
. 2020 Mar;
38(13):1409-1418.
PMID: 32125938
Purpose: To determine the sensitivity and specificity of genetic testing criteria for the detection of germline pathogenic variants in women with breast cancer. Materials And Methods: Women with breast cancer...
9.
Zhang C, Kemp R, Stothard P, Wang Z, Boddicker N, Krivushin K, et al.
Genet Sel Evol
. 2018 Apr;
50(1):14.
PMID: 29625549
Background: Increasing marker density was proposed to have potential to improve the accuracy of genomic prediction for quantitative traits; whole-sequence data is expected to give the best accuracy of prediction,...
10.
Zhang C, Bruce H, Yang T, Charagu P, Kemp R, Boddicker N, et al.
PLoS One
. 2016 Feb;
11(2):e0145082.
PMID: 26901498
Of all the meat quality traits, tenderness is considered the most important with regard to eating quality and market value. In this study we have utilised genome wide association studies...