Nicholas B Whitticar
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Explore the profile of Nicholas B Whitticar including associated specialties, affiliations and a list of published articles.
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9
Citations
80
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Recent Articles
1.
Whitticar N, Nunemaker C
Biophysicist (Rockv)
. 2022 Jun;
1(2).
PMID: 35647498
Recruiting talented high school and college students to consider a career in the biomedical or biophysical sciences is important, yet often difficult. Encouraging students in regions like Appalachia adds additional...
2.
DAngelo C, West H, Whitticar N, Corbin K, Donovan L, Stiadle B, et al.
Endocrinology
. 2022 May;
163(7).
PMID: 35551371
Pulsatility is important to islet function. As islets mature into fully developed insulin-secreting micro-organs, their ability to produce oscillatory intracellular calcium ([Ca2+]i) patterns in response to glucose also matures. In...
3.
Gerber K, Whitticar N, Rochester D, Corbin K, Koch W, Nunemaker C
Metabolites
. 2021 Jul;
11(6).
PMID: 34205432
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the...
4.
Duran-Ortiz S, Corbin K, Jahan I, Whitticar N, Morris S, Bartholomew A, et al.
Am J Physiol Endocrinol Metab
. 2021 May;
320(6):E1158-E1172.
PMID: 33938235
In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline...
5.
Chen X, Daniels N, Cottrill D, Cao Y, Wang X, Li Y, et al.
Diabetes Metab Syndr Obes
. 2021 Mar;
14:759-772.
PMID: 33658814
Purpose: Previously we showed that natural compound α-penta-galloyl-glucose (α-PGG) and its synthetic derivative 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose (6Cl-TGQ) act to improve insulin signaling in adipocytes by increasing glucose transport. In this study, we...
6.
Corbin K, West H, Brodsky S, Whitticar N, Koch W, Nunemaker C
Biol Proced Online
. 2021 Mar;
23(1):7.
PMID: 33641671
Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is...
7.
Whitticar N, Nunemaker C
Front Endocrinol (Lausanne)
. 2020 Jun;
11:378.
PMID: 32582035
Pancreatic beta-cells are the only cells in the body that can synthesize and secrete insulin. Through the process of glucose-stimulated insulin secretion, beta-cells release insulin into circulation, stimulating GLUT4-dependent glucose...
8.
Jahan I, Corbin K, Bogart A, Whitticar N, Waters C, Schildmeyer C, et al.
Endocrinology
. 2018 Sep;
159(11):3747-3760.
PMID: 30239634
An early sign of islet failure in type 2 diabetes (T2D) is the loss of normal patterns of pulsatile insulin release. Disruptions in pulsatility are associated with a left shift...
9.
Whitticar N, Strahler E, Rajan P, Kaya S, Nunemaker C
Biol Proced Online
. 2016 Nov;
18:19.
PMID: 27895534
Background: Cells are continuously exposed to changes in their environment. Endocrine systems, in particular, communicate by rhythms and feedback loops. In this study, we developed an automated system to produce...