Nicholas B Hamilton
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Explore the profile of Nicholas B Hamilton including associated specialties, affiliations and a list of published articles.
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4
Citations
4
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Recent Articles
1.
Hamilton N, Yang B, Xiang C, Li T, Schneebeli S, Li J
bioRxiv
. 2025 Feb;
PMID: 39974954
The pituitary adenylate cyclase-activating polypeptide receptor I (PAC1R) represents a highly sought-after therapeutic target for chronic pain, migraine, and post-traumatic stress. As a class B G protein-coupled receptor (GPCR), the...
2.
Hamilton N, Arns S, Shelley M, Bechis I, Shelley J
Mol Pharm
. 2024 Dec;
22(1):588-593.
PMID: 39655829
Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent p...
3.
Grzetic D, Hamilton N, Shelley J
Mol Pharm
. 2024 Aug;
21(9):4747-4753.
PMID: 39145436
Ionizable lipid-containing lipid nanoparticles (LNPs) have enabled the delivery of RNA for a range of therapeutic applications. In order to optimize safe, targeted, and effective LNP-based RNA delivery platforms, an...
4.
Mustafa R, Fitian M, Hamilton N, Li J, Silva W, Punihaole D
J Phys Chem B
. 2022 Oct;
126(42):8404-8414.
PMID: 36222425
Establishing how polymeric vectors such as polyethylenimine (PEI) bind and package their nucleic acid cargo is vital toward developing more efficacious and cost-effective gene therapies. To develop a molecular-level picture...
5.
McKay K, Hamilton N, Remington J, Schneebeli S, Li J
Front Mol Biosci
. 2022 Jul;
9:879212.
PMID: 35847975
The lack of biologically relevant protein structures can hinder rational design of small molecules to target G protein-coupled receptors (GPCRs). While ensemble docking using multiple models of the protein target...