Nicholas A Pease
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Explore the profile of Nicholas A Pease including associated specialties, affiliations and a list of published articles.
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11
Citations
104
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Recent Articles
1.
Pease N, Denecke K, Chen L, Gerges P, Kueh H
Development
. 2024 Dec;
151(23.
PMID: 39655434
How multipotent progenitors give rise to multiple cell types in defined numbers is a central question in developmental biology. Epigenetic switches, acting at single gene loci, can generate extended delays...
2.
Nguyen P, Pease N, Kueh H
J R Soc Interface
. 2021 Jul;
18(180):20210109.
PMID: 34283940
During development, progenitor cells follow timetables for differentiation that span many cell generations. These developmental timetables are robustly encoded by the embryo, yet scalably adjustable by evolution, facilitating variation in...
3.
Woodworth M, Ng K, Halpern A, Pease N, Nguyen P, Kueh H, et al.
Nucleic Acids Res
. 2021 May;
49(14):e82.
PMID: 34048564
Proper regulation of genome architecture and activity is essential for the development and function of multicellular organisms. Histone modifications, acting in combination, specify these activity states at individual genomic loci....
4.
Abadie K, Pease N, Wither M, Kueh H
Curr Opin Syst Biol
. 2021 Apr;
18:95-103.
PMID: 33791444
To protect against diverse challenges, the immune system must continuously generate an arsenal of specialized cell types, each of which can mount a myriad of effector responses upon detection of...
5.
Pease N, Nguyen P, Woodworth M, Ng K, Irwin B, Vaughan J, et al.
Cell Rep
. 2021 Mar;
34(12):108888.
PMID: 33761349
During development, progenitors often differentiate many cell generations after receiving signals. These delays must be robust yet tunable for precise population size control. Polycomb repressive mechanisms, involving histone H3 lysine-27...
6.
Chu J, Pease N, Kueh H
Immunol Rev
. 2021 Mar;
300(1):134-151.
PMID: 33734444
Proper timing of gene expression is central to lymphocyte development and differentiation. Lymphocytes often delay gene activation for hours to days after the onset of signaling components, which act on...
7.
Pease N, Shephard M, Sertorio M, Waltz S, Privette Vinnedge L
Cancers (Basel)
. 2020 Jul;
12(7).
PMID: 32708944
Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers and is...
8.
Steach H, DeBuysscher B, Schwartz A, Boonyaratanakornkit J, Baker M, Tooley M, et al.
J Immunol
. 2019 Dec;
204(3):498-509.
PMID: 31882518
Upon Ag exposure, naive B cells expressing BCR able to bind Ag can undergo robust proliferation and differentiation that can result in the production of Ab-secreting and memory B cells....
9.
Serrano-Lopez J, Nattamai K, Pease N, Shephard M, Wellendorf A, Sertorio M, et al.
Exp Hematol
. 2017 Dec;
59:40-50.e3.
PMID: 29288703
Self-renewing hematopoietic stem cells and multipotent progenitor cells are responsible for maintaining hematopoiesis throughout an individual's lifetime. For overall health and survival, it is critical that the genome stability of...
10.
Ghisays V, Nguyen E, Streicher J, Pease N, Fitzgerald M, Estrada C, et al.
Neuroscience
. 2017 Nov;
371:254-267.
PMID: 29175155
DEK, a chromatin-remodeling gene expressed in most human tissues, is known for its role in cancer biology and autoimmune diseases. DEK depletion in vitro reduces cellular proliferation, induces DNA damage...