Nicholas A Castello
Overview
Explore the profile of Nicholas A Castello including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
906
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0
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Recent Articles
1.
Blurton-Jones M, Spencer B, Michael S, Castello N, Agazaryan A, Davis J, et al.
Stem Cell Res Ther
. 2024 Mar;
15(1):88.
PMID: 38523285
No abstract available.
2.
Linsley J, Linsley D, Lamstein J, Ryan G, Shah K, Castello N, et al.
Sci Adv
. 2021 Dec;
7(50):eabf8142.
PMID: 34878844
Cellular events underlying neurodegenerative disease may be captured by longitudinal live microscopy of neurons. While the advent of robot-assisted microscopy has helped scale such efforts to high-throughput regimes with the...
3.
Fang M, Markmiller S, Vu A, Javaherian A, Dowdle W, Jolivet P, et al.
Neuron
. 2019 Jul;
103(5):802-819.e11.
PMID: 31272829
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To yield insights into the role of SGs...
4.
Czirr E, Castello N, Mosher K, Castellano J, Hinkson I, Lucin K, et al.
J Exp Med
. 2017 Mar;
214(4):1081-1092.
PMID: 28298456
Recent genetic evidence supports a link between microglia and the complement system in Alzheimer's disease (AD). In this study, we uncovered a novel role for the microglial complement receptor 3...
5.
Lin A, Liu G, Castello N, Yeh J, Rahimian R, Lee G, et al.
Neurophotonics
. 2014 Aug;
1(1):011005.
PMID: 25133200
Alzheimer's disease (AD) and cerebrovascular disease are often comorbid conditions, but the relationship between amyloid- and vascular pathophysiology is poorly understood. We utilized a multimodal, multiscale optical imaging approach, including...
6.
Blurton-Jones M, Spencer B, Michael S, Castello N, Agazaryan A, Davis J, et al.
Stem Cell Res Ther
. 2014 Jul;
5(2):46.
PMID: 25022790
Introduction: Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid...
7.
Castello N, Nguyen M, Tran J, Cheng D, Green K, LaFerla F
PLoS One
. 2014 Mar;
9(3):e91453.
PMID: 24614170
Augmenting BDNF/TrkB signaling has been demonstrated to be a promising strategy for reversing cognitive deficits in preclinical models of Alzheimer disease (AD). Although these studies highlight the potential of targeting...
8.
Chabrier M, Cheng D, Castello N, Green K, LaFerla F
Neurobiol Dis
. 2014 Jan;
64:107-17.
PMID: 24440055
Synapse number is the best indicator of cognitive impairment In Alzheimer's disease (AD), yet the respective contributions of Aβ and tau, particularly human wild-type tau, to synapse loss remain undefined....
9.
Lin A, Castello N, Lee G, Green K, Durkin A, Choi B, et al.
Lasers Surg Med
. 2013 Nov;
46(1):27-33.
PMID: 24284732
Background: There currently is a need for cost-effective, quantitative techniques to evaluate the gradual progression of Alzheimer's disease (AD). Measurement techniques based on diffuse optical spectroscopy can detect blood perfusion...
10.
Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto-Vargas D, Green K, et al.
Am J Pathol
. 2013 Nov;
184(2):520-9.
PMID: 24269557
Alzheimer disease (AD) is a progressive neurodegenerative disorder with associated memory loss, spatial disorientation, and other psychiatric problems. Cholinergic system dysfunction is an early and salient feature of AD, and...