Nesli-Ece Sen
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Explore the profile of Nesli-Ece Sen including associated specialties, affiliations and a list of published articles.
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9
Citations
127
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Recent Articles
1.
Boeynaems S, Dorone Y, Zhuang Y, Shabardina V, Huang G, Marian A, et al.
Mol Cell
. 2023 Jun;
83(12):2020-2034.e6.
PMID: 37295429
Biomolecular condensation underlies the biogenesis of an expanding array of membraneless assemblies, including stress granules (SGs), which form under a variety of cellular stresses. Advances have been made in understanding...
2.
Canet-Pons J, Sen N, Arsovic A, Almaguer-Mederos L, Halbach M, Key J, et al.
Neurobiol Dis
. 2021 Feb;
152:105289.
PMID: 33577922
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective motor neuron degeneration, known as Amyotrophic...
3.
Arsovic A, Halbach M, Canet-Pons J, Esen-Sehir D, Doring C, Freudenberg F, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32932600
Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca) homeostasis after stimuli....
4.
Key J, Harter P, Sen N, Gradhand E, Auburger G, Gispert S
Int J Mol Sci
. 2020 Jul;
21(14).
PMID: 32698485
Depletion of yeast/fly Ataxin-2 rescues TDP-43 overexpression toxicity. In mouse models of Amyotrophic Lateral Sclerosis via TDP-43 overexpression, depletion of its ortholog ATXN2 mitigated motor neuron degeneration and extended lifespan...
5.
Sen N, Arsovic A, Meierhofer D, Brodesser S, Oberschmidt C, Canet-Pons J, et al.
Int J Mol Sci
. 2019 Nov;
20(23).
PMID: 31766565
Ataxin-2 (human gene symbol ) acts during stress responses, modulating mRNA translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance. Conversely, the progressive ATXN2 gain...
6.
Sen N, Canet-Pons J, Halbach M, Arsovic A, Pilatus U, Chae W, et al.
Neurobiol Dis
. 2019 Aug;
132:104559.
PMID: 31376479
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder caused by CAG-expansion mutations in the ATXN2 gene, mainly affecting motor neurons in the spinal cord and Purkinje neurons...
7.
Auburger G, Gispert S, Torres-Odio S, Jendrach M, Brehm N, Canet-Pons J, et al.
Int J Mol Sci
. 2019 Jul;
20(13).
PMID: 31277379
Hereditary Parkinson's disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We demonstrated...
8.
Auburger G, Sen N, Meierhofer D, Basak A, Gitler A
Trends Neurosci
. 2017 Jul;
40(8):507-516.
PMID: 28684172
Ataxin-2 (ATXN2) homologs exist in all eukaryotic organisms and may have contributed to their origin. Apart from a role in endocytosis, they are known for global effects on mRNA repair...
9.
Seidel G, Meierhofer D, Sen N, Guenther A, Krobitsch S, Auburger G
J Proteome Res
. 2016 Dec;
16(2):504-515.
PMID: 27966978
The yeast protein PBP1 is implicated in very diverse pathways. Intriguingly, its deletion mitigates the toxicity of human neurodegeneration factors. Here, we performed label-free quantitative global proteomics to identify crucial...