Nenggang Zhang
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Explore the profile of Nenggang Zhang including associated specialties, affiliations and a list of published articles.
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30
Citations
651
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Recent Articles
1.
Kumar P, Zhang N, Lee J, Cheng H, Kurtz K, Conneely S, et al.
Stem Cells
. 2023 Aug;
41(10):971-985.
PMID: 37534584
Recent studies suggest that chromosomal cohesin complex proteins are important in regulating hematopoiesis and may contribute to myeloid malignancies. To investigate the effects of perturbing the cohesin subunit protein RAD21...
2.
Zhang N, Lin K, Yang C, Peruski S, Pati D, Gilbertson S
ChemMedChem
. 2022 Jan;
17(9):e202100653.
PMID: 35018729
STAG2 (SA2) is a critical component of the cohesin complex that regulates gene expression and the separation of sister chromatids in cells. Mutations in STAG2 have been identified in over...
3.
Zhang N, Coutinho L, Pati D
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34070827
Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays...
4.
Kumar P, Cheng H, Paudyal S, Nakamura L, Zhang N, Li J, et al.
Stem Cells
. 2020 Sep;
PMID: 32997844
Cohesin recently emerged as a new regulator of hematopoiesis and leukemia. In addition to cohesin, whether proteins that regulate cohesin's function have any direct role in hematopoiesis and hematologic diseases...
5.
Cheng H, Zhang N, Pati D
Gene
. 2020 Jul;
758:144966.
PMID: 32687945
RAD21 (also known as KIAA0078, NXP1, HR21, Mcd1, Scc1, and hereafter called RAD21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all...
6.
Zhang N, Sarkar A, Pati D
Data Brief
. 2020 Feb;
29:105159.
PMID: 32071959
Separase Inhibitor-Sepin-1 has shown great promise as a developmental chemotherapeutic agent to treat Separase-overexpressing tumors, however, very little is known about its toxicity profile. Here we present the data set...
7.
Zhang N, Sarkar A, Li F, Demerzhan S, Gilbertson S, Pati D
Biochem Pharmacol
. 2020 Jan;
174:113808.
PMID: 31930961
Separase, a sister chromatid cohesion-resolving enzyme, is an oncogene and overexpressed in many human cancers. Sepin-1 (2,2-dimethyl-5-nitro-2H-benzimidazole-1,3-dioxide) is a potent separase inhibitor that impedes cancer cell growth, cell migration, and...
8.
Zhang N, Sarkar A, Pati D
Pathol Res Pract
. 2019 Dec;
216(1):152730.
PMID: 31784093
Sepin-1 is a small compound that inhibits enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, herein...
9.
Li F, Zhang N, Gorantla S, Gilbertson S, Pati D
Front Pharmacol
. 2018 Jun;
9:313.
PMID: 29867452
Separase, a known oncogene, is widely overexpressed in numerous human tumors of breast, bone, brain, blood, and prostate. Separase is an emerging target for cancer therapy, and separase enzymatic inhibitors...
10.
Zhang N, Pati D
J Cancer Sci Ther
. 2018 May;
10(3).
PMID: 29780443
Sepin-1, a potent non-competitive inhibitor of separase, inhibits cancer cell growth, but the mechanisms of Sepin-1-mediated growth inhibition are not fully understood. Here we report that Sepin-1 hinders growth of...