Nelson E Brown
Overview
Explore the profile of Nelson E Brown including associated specialties, affiliations and a list of published articles.
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9
Citations
251
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Recent Articles
1.
Cayo A, Venturini W, Rebolledo-Mira D, Moore-Carrasco R, Herrada A, Nova-Lamperti E, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298236
Despite not dividing, senescent cells acquire the ability to synthesize and secrete a plethora of bioactive molecules, a feature known as the senescence-associated secretory phenotype (SASP). In addition, senescent cells...
2.
Venturini W, Olate-Briones A, Valenzuela C, Mendez D, Fuentes E, Cayo A, et al.
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32384773
Aging is one of the main risk factors for the development of chronic diseases, with both the vascular endothelium and platelets becoming functionally altered. Cellular senescence is a form of...
3.
Valenzuela C, Quintanilla R, Olate-Briones A, Venturini W, Mancilla D, Cayo A, et al.
Int J Mol Sci
. 2019 Oct;
20(21).
PMID: 31653055
Alterations in platelet aggregation are common in aging individuals and in the context of age-related pathologies such as cancer. So far, however, the effects of senescent cells on platelets have...
4.
Valenzuela C, Vargas L, Martinez V, Bravo S, Brown N
Exp Cell Res
. 2017 Sep;
360(2):390-396.
PMID: 28947133
Targeting cyclin D-CDK4/6 kinase complexes has recently been shown to increase the survival of breast cancer patients with estrogen receptor positive breast tumors. Based on these outcomes, CDK4/6 inhibitors are...
5.
Valenzuela C, Quintanilla R, Moore-Carrasco R, Brown N
Front Oncol
. 2017 Sep;
7:188.
PMID: 28894697
In addition to thrombus formation, alterations in platelet function are frequently observed in cancer patients. Importantly, both thrombus and tumor formation are influenced by age, although the mechanisms through which...
6.
Brown N, Jeselsohn R, Bihani T, Hu M, Foltopoulou P, Kuperwasser C, et al.
Cancer Res
. 2012 Oct;
72(24):6477-89.
PMID: 23041550
Overexpression of cyclin D1 is believed to endow mammary epithelial cells (MEC) with a proliferative advantage by virtue of its contribution to pRB inactivation. Accordingly, abrogation of the kinase-dependent function...
7.
Jeselsohn R, Brown N, Arendt L, Klebba I, Hu M, Kuperwasser C, et al.
Cancer Cell
. 2010 Feb;
17(1):65-76.
PMID: 20129248
Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self-renew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogenic...
8.
Gutierrez G, Kong E, Sabbagh Y, Brown N, Lee J, Demay M, et al.
Proc Natl Acad Sci U S A
. 2008 Nov;
105(47):18402-7.
PMID: 19020086
We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also plays a role early in...
9.
Landis M, Brown N, Baker G, Shifrin A, Das M, Geng Y, et al.
Cancer Res
. 2007 Aug;
67(16):7613-20.
PMID: 17699765
Cyclin D1 is a multifunctional, tumor-associated protein that interacts with pRb via a conserved LxCxE motif, activates a kinase partner, directs the phosphorylation of pRb, activates cyclin E-cyclin-dependent kinase 2...