Nelli Erwin
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Explore the profile of Nelli Erwin including associated specialties, affiliations and a list of published articles.
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20
Citations
187
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Recent Articles
1.
Stange C, Hafiz S, Erwin N, Hafner M, Frech C
J Chromatogr B Analyt Technol Biomed Life Sci
. 2022 Dec;
1214:123563.
PMID: 36525885
Aggregation of proteins is a critical quality attribute and a major concern during the purification of therapeutic proteins, like monoclonal antibodies. In-solution experiments applying different stress scenarios, e.g., mechanical, or...
2.
Zoeller M, Hafiz S, Marx A, Erwin N, Fricker G, Carpenter J
J Pharm Sci
. 2022 Sep;
111(12):3261-3274.
PMID: 36096287
The application of surfactants in liquid protein formulation is a common practice to protect proteins from liquid-air interface-induced protein aggregation. Typically, Polysorbate 20 or 80 are used, but degradation of...
3.
Salvador-Castell M, Golub M, Erwin N, Deme B, Brooks N, Winter R, et al.
Commun Biol
. 2021 Jun;
4(1):653.
PMID: 34079059
It has been proposed that adaptation to high temperature involved the synthesis of monolayer-forming ether phospholipids. Recently, a novel membrane architecture was proposed to explain the membrane stability in polyextremophiles...
4.
Weil T, Gross R, Rocker A, Bravo-Rodriguez K, Heid C, Sowislok A, et al.
J Am Chem Soc
. 2020 Sep;
142(40):17024-17038.
PMID: 32926779
Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular...
5.
Laraia L, Friese A, Corkery D, Konstantinidis G, Erwin N, Hofer W, et al.
Nat Chem Biol
. 2019 Jun;
15(7):710-720.
PMID: 31222192
Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and plays a key role in health and disease. Thus, the identification of new mechanisms involved in the regulation of...
6.
Li L, Erwin N, Mobitz S, Niemeyer F, Schrader T, Winter R
Chemistry
. 2019 May;
25(42):9827-9833.
PMID: 31141233
Oncogenic Ras mutations occur in more than 30 % of human cancers. K-Ras4B is the most frequently mutated isoform of Ras proteins. Development of effective K-Ras4B inhibitors has been challenging,...
7.
Li L, Dwivedi M, Patra S, Erwin N, Mobitz S, Winter R
Chembiochem
. 2019 Jan;
20(9):1190-1195.
PMID: 30604476
Signaling of N-Ras and K-Ras4B proteins depends strongly on their correct localization in the cell membrane. In vivo studies suggest that intermolecular interactions foster the self-association of both N-Ras and...
8.
Erwin N, Dwivedi M, Mejuch T, Waldmann H, Winter R
Chembiochem
. 2018 Apr;
19(14):1482-1487.
PMID: 29700916
Plasma membrane localization of myristoylated c-Src, a proto-oncogene protein-tyrosine kinase, is required for its signaling activity. Recent studies proposed that UNC119 protein functions as a solubilizing factor for myristoylated proteins,...
9.
Gao M, Berghaus M, Mobitz S, Schuabb V, Erwin N, Herzog M, et al.
Biophys J
. 2018 Mar;
114(5):1080-1090.
PMID: 29539395
For over 50 years, it has been known that the mitosis of eukaryotic cells is inhibited already at high hydrostatic pressure conditions of 30 MPa. This effect has been attributed...
10.
Li L, Dwivedi M, Erwin N, Mobitz S, Nussbaumer P, Winter R
Biochim Biophys Acta Biomembr
. 2018 Jan;
1860(5):1008-1014.
PMID: 29357287
Ras proteins are oncoproteins which play a pivotal role in cellular signaling pathways. All Ras proteins' signaling strongly depends on their correct localization in the cell membrane. Over 30% of...