Neill J Liptrott
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Explore the profile of Neill J Liptrott including associated specialties, affiliations and a list of published articles.
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45
Citations
476
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Recent Articles
1.
Hannon G, Heaton B, Plant-Hately A, David C, Liptrott N, Egizabal A, et al.
Nanoscale
. 2024 Oct;
16(45):21011-21020.
PMID: 39445396
Endotoxin contamination is a significant hurdle to the translation of nanomaterials for biomedical applications. Multiple reports now describe that more than one-third of nanomaterials fail early pre-clinical assessment due to...
2.
David C, Vermeulen J, Gioria S, Vandebriel R, Liptrott N
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791527
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate...
3.
da Silva T, Rendra E, David C, Bieback K, Cross M, Wilm B, et al.
Biomed Pharmacother
. 2023 Oct;
167:115624.
PMID: 37783151
Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a role for secreted factors, such as MSC-derived extracellular...
4.
Pichardo A, Wilm B, Liptrott N, Murray P
Stem Cells Int
. 2023 Sep;
2023:7397819.
PMID: 37705699
Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in preclinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment...
5.
Sposito F, Pennington S, David C, Duggan J, Northey S, Biagini G, et al.
Mucosal Immunol
. 2023 Aug;
16(6):776-787.
PMID: 37574128
Young age and high vitamin D plasma levels have been associated with lower SARS-CoV-2 infection risk and favourable disease outcomes. This study investigated mechanisms associated with differential responses to SARS-CoV-2...
6.
Curley P, Hobson J, Liptrott N, Makarov E, Al-Khouja A, Tatham L, et al.
Pharmaceutics
. 2023 Jul;
15(7).
PMID: 37514020
Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported...
7.
Application of KU812 cells for assessing complement activation related effects by nano(bio)materials
David C, de la Fonteyne-Blankestijn L, Vermeulen J, Plant-Hately A, Vandebriel R, Liptrott N
Biomed Pharmacother
. 2023 May;
163:114841.
PMID: 37167727
Immunocompatibility issues related to nano(bio)materials, particularly liposomal formulations, involving activation of the complement system have been relatively well described however, they highlight the importance of preclinical evaluation of such interactions....
8.
Amadeo F, Hanson V, Liptrott N, Wilm B, Murray P, Taylor A
Biomed Pharmacother
. 2023 Jan;
159:114191.
PMID: 36623449
Mesenchymal stromal cells (MSCs) are multipotent cells showing promise in pre-clinical studies and currently used in many clinical trials. The regenerative potential of MSCs is mediated, at least in part,...
9.
Plant-Hately A, Eryilmaz B, David C, Brain D, Heaton B, Perrie Y, et al.
Pharmaceutics
. 2022 Nov;
14(11).
PMID: 36432660
Lipidic nanoparticles (LNP), particularly liposomes, have been proven to be a successful and versatile platform for intracellular drug delivery for decades. Whilst primarily developed for small molecule delivery, liposomes have...
10.
Vandebriel R, David C, Vermeulen J, Liptrott N
Drug Deliv Transl Res
. 2022 Jul;
12(9):2225-2242.
PMID: 35838879
Nanoparticles including nanomedicines are known to be recognised by and interact with the immune system. As these interactions may result in adverse effects, for safety evaluation, the presence of such...