Neil W Isaacs
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Explore the profile of Neil W Isaacs including associated specialties, affiliations and a list of published articles.
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42
Citations
700
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Recent Articles
1.
McLuskey K, Rudolf J, Proto W, Isaacs N, Coombs G, Moss C, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(19):7469-74.
PMID: 22529389
Metacaspases are distantly related caspase-family cysteine peptidases implicated in programmed cell death in plants and lower eukaryotes. They differ significantly from caspases because they are calcium-activated, arginine-specific peptidases that do...
2.
Roszak A, Moulisova V, Reksodipuro A, Gardiner A, Fujii R, Hashimoto H, et al.
Biochem J
. 2011 Nov;
442(1):27-37.
PMID: 22054235
Newly determined crystal structures of the photosynthetic RC (reaction centre) from two substrains of the non-sulfur purple bacterium Blastochloris viridis strain DSM 133, together with analysis of their gene sequences,...
3.
Gabrielsen M, Kroner F, Black I, Isaacs N, Roe A, McLuskey K
Mol Membr Biol
. 2011 Nov;
28(7-8):445-53.
PMID: 22034843
An important factor in the crystallization, and subsequent structural determination, of integral membrane proteins is the ability to produce a stable and monodisperse solution of the protein. Obtaining the correct...
4.
Hounsome J, Baillie S, Noofeli M, Riboldi-Tunnicliffe A, Burchmore R, Isaacs N, et al.
Infect Immun
. 2011 Sep;
79(11):4332-41.
PMID: 21896777
Mannheimia haemolytica is the etiological agent of pneumonic pasteurellosis of cattle and sheep; two different OmpA subclasses, OmpA1 and OmpA2, are associated with bovine and ovine isolates, respectively. These proteins...
5.
Cogdell R, Gardiner A, Roszak A, Stoncius S, Kocovsky P, Isaacs N
Biochem Soc Trans
. 2011 May;
39(3):775-9.
PMID: 21599648
Electron-density maps for the crystal structures of membrane proteins often show features suggesting binding of lipids and/or detergent molecules on the hydrophobic surface, but usually it is difficult to identify...
6.
Zhai Y, Zhang K, Huo Y, Zhu Y, Zhou Q, Lu J, et al.
Biochem J
. 2011 Feb;
435(3):577-87.
PMID: 21306302
Whooping cough (pertussis) is a highly contagious acute respiratory illness of humans caused by the Gram-negative bacterial pathogen Bordetella pertussis. The AT (autotransporter) BrkA (Bordetella serum-resistance killing protein A) is...
7.
Gabrielsen M, Zetterstrom C, Wang D, Beckham K, Elofsson M, Isaacs N, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Dec;
66(Pt 12):1606-9.
PMID: 21139206
Thiol peroxidase is an atypical 2-Cys peroxiredoxin that reduces alkyl hydroperoxides. Wild-type and C61S mutant protein have been recombinantly expressed in Escherichia coli and purified using nickel-affinity chromatography. Initial crystallization...
8.
McLuskey K, Paterson N, Bland N, Isaacs N, Mottram J
J Biol Chem
. 2010 Oct;
285(50):39249-59.
PMID: 20926390
Oligopeptidase B (OPB) is a serine peptidase with dibasic substrate specificity. It is found in bacteria, plants, and trypanosomatid pathogens, where it has been identified as a virulence factor and...
9.
Horsham M, Saxby H, Blake J, Isaacs N, Mitchell T, Riboldi-Tunnicliffe A
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Aug;
66(Pt 8):899-901.
PMID: 20693662
The enzyme transketolase from the lactic acid bacterium Lactobacillus salivarius (subsp. salivarius UCC118) has been recombinantly expressed and purified using an Escherichia coli expression system. Purified transketolase from L. salivarius...
10.
Gabrielsen M, Abdul-Rahman P, Isaacs N, Hashim O, Cogdell R
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 May;
66(Pt 5):592-4.
PMID: 20445267
Mannose-binding lectin from champedak (Artocarpus integer) is a homotetramer with a single-monomer molecular weight of 16 800 Da. Previous work has shown it to bind IgE and IgM, as well...