Neil Kelleher
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Explore the profile of Neil Kelleher including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
675
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0
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Recent Articles
1.
Lu D, Faizi M, Drown B, Simerzin A, Francois J, Bradshaw G, et al.
Sci Adv
. 2024 Oct;
10(43):eadp2229.
PMID: 39454005
The master regulator of the DNA damage response, the transcription factor p53, orchestrates multiple downstream responses and coordinates repair processes. In response to double-strand DNA breaks, p53 exhibits pulses of...
2.
Gantner B, Palma F, Kayzuka C, Lacchini R, Foltz D, Backman V, et al.
Trends Genet
. 2024 Jun;
40(9):739-746.
PMID: 38910033
The emergence of aerobic respiration created unprecedented bioenergetic advantages, while imposing the need to protect critical genetic information from reactive byproducts of oxidative metabolism (i.e., reactive oxygen species, ROS). The...
3.
Lermyte F, Habeck T, Brown K, Des Soye B, Lantz C, Zhou M, et al.
Res Sq
. 2023 Sep;
PMID: 37674709
The combination of native electrospray ionisation with top-down fragmentation in mass spectrometry allows simultaneous determination of the stoichiometry of noncovalent complexes and identification of their component proteoforms and co-factors. While...
4.
Yates 3rd J, Gomes F, Durbin K, Schauer K, Nwachukwu J, Russo R, et al.
Res Sq
. 2023 Aug;
PMID: 37546719
Oligomerization of proteins and their modified forms (proteoforms) produces functional protein complexes . Complexoforms are complexes that consist of the same set of proteins with different proteoforms . The ability...
5.
Ling T, Birger Y, Stankiewicz M, Ben-Haim N, Kalisky T, Rein A, et al.
Blood
. 2019 Aug;
134(19):1619-1631.
PMID: 31409672
Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1 N terminus, are seen in patients with Diamond-Blackfan anemia (DBA). In our efforts to better...
6.
Harris D, Lukoyanov D, Kallas H, Trncik C, Yang Z, Compton P, et al.
Biochemistry
. 2019 Jul;
58(30):3293-3301.
PMID: 31283201
Three genetically distinct, but structurally similar, isozymes of nitrogenase catalyze biological N reduction to 2NH: Mo-, V-, and Fe-nitrogenase, named respectively for the metal () in their active site metallocofactors...
7.
Harris D, Lukoyanov D, Shaw S, Compton P, Tokmina-Lukaszewska M, Bothner B, et al.
Biochemistry
. 2017 Dec;
57(5):701-710.
PMID: 29283553
Of the three forms of nitrogenase (Mo-nitrogenase, V-nitrogenase, and Fe-nitrogenase), Fe-nitrogenase has the poorest ratio of N reduction relative to H evolution. Recent work on the Mo-nitrogenase has revealed that...
8.
Ezponda T, Dupere-Richer D, Will C, Small E, Varghese N, Patel T, et al.
Cell Rep
. 2017 Oct;
21(3):628-640.
PMID: 29045832
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to...
9.
Zhou Y, Zhang X, Fornelli L, Compton P, Kelleher N, Wirth M
J Chromatogr B Analyt Technol Biomed Life Sci
. 2017 Jan;
1044-1045:47-53.
PMID: 28076774
Histones are involved in epigenetic control of a wide variety of cellular processes through their multiple post-translational modifications. Their strongly cationic nature makes them challenging to separate with reversed-phase liquid...
10.
Beguelin W, Popovic R, Teater M, Jiang Y, Bunting K, Rosen M, et al.
Cancer Cell
. 2013 May;
23(5):677-92.
PMID: 23680150
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic...