Neil Humphreys
Overview
Explore the profile of Neil Humphreys including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
18
Citations
371
Followers
0
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Recent Articles
1.
Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo
Formichetti S, Sadowska A, Ascolani M, Hansen J, Ganter K, Lancrin C, et al.
PLoS Genet
. 2025 Jan;
21(1):e1011507.
PMID: 39787076
The reversible glycosylation of nuclear and cytoplasmic proteins (O-GlcNAcylation) is catalyzed by a single enzyme, namely O-GlcNAc transferase (OGT). The mammalian Ogt gene is X-linked, and it is essential for...
2.
Argaw-Denboba A, Schmidt T, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, et al.
Nature
. 2024 May;
629(8012):652-659.
PMID: 38693261
The gut microbiota operates at the interface of host-environment interactions to influence human homoeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore shape physiological and disease-associated...
3.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva N, Simon Futers T, Parsonage G, et al.
Liver Int
. 2023 Jun;
43(9):2026-2038.
PMID: 37349903
Background & Aims: PIEZO1 and TRPV4 are mechanically and osmotically regulated calcium-permeable channels. The aim of this study was to determine the relevance and relationship of these channels in the...
4.
Chuntharpursat-Bon E, Povstyan O, Ludlow M, Carrier D, Debant M, Shi J, et al.
Commun Biol
. 2023 Apr;
6(1):358.
PMID: 37005489
Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1 channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell adhesion molecule...
5.
Talbot F, Feetham C, Mokrosinski J, Lawler K, Keogh J, Henning E, et al.
Nat Commun
. 2023 Mar;
14(1):1450.
PMID: 36922513
Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These...
6.
Gurumurthy C, OBrien A, Quadros R, Adams Jr J, Alcaide P, Ayabe S, et al.
Genome Biol
. 2021 Apr;
22(1):99.
PMID: 33827648
No abstract available.
7.
Hunter A, Pelekanou C, Adamson A, Downton P, Barron N, Cornfield T, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(41):25869-25879.
PMID: 32989157
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP-sequencing of REVERBα in mouse...
8.
Yang N, Smyllie N, Morris H, Goncalves C, Dudek M, Pathiranage D, et al.
PLoS Genet
. 2020 May;
16(4):e1008729.
PMID: 32352975
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is...
9.
Gurumurthy C, OBrien A, Quadros R, Adams Jr J, Alcaide P, Ayabe S, et al.
Genome Biol
. 2019 Aug;
20(1):171.
PMID: 31446895
Background: CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16%...
10.
Sefton C, Davies A, Allen T, Wray J, Shoop R, Adamson A, et al.
Endocrinology
. 2019 Feb;
160(5):964-978.
PMID: 30794724
Glucocorticoids are potent and widely used medicines but often cause metabolic side effects. A murine model of corticosterone treatment resulted in increased hypothalamic expression of the melanocortin antagonist AgRP in...