Neil D Telling
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Explore the profile of Neil D Telling including associated specialties, affiliations and a list of published articles.
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25
Citations
484
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Recent Articles
1.
Nahar T, Gates M, Secret E, Siaugue J, Fresnais J, Rotherham M, et al.
Acta Biomater
. 2025 Jan;
193:215-230.
PMID: 39755241
The ability to control the growth and orientation of neurites over long distances has significant implications for regenerative therapies and the development of physiologically relevant brain tissue models. In this...
2.
Everett J, Brooks J, Tjhin V, Lermyte F, Hands-Portman I, Plascencia-Villa G, et al.
ACS Chem Neurosci
. 2024 Mar;
15(7):1469-1483.
PMID: 38501754
The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer's disease. Altered metabolism of essential biometals is another feature of Alzheimer's, with amyloid plaques representing...
3.
Cabrera D, Sharifabad M, Ranjbar J, Telling N, Harper A
J Thromb Haemost
. 2022 Aug;
20(11):2556-2570.
PMID: 35950914
Background: Thrombolysis is a frontline treatment for stroke, which involves the application of tissue plasminogen activator (tPA) to trigger endogenous clot-degradation pathways. However, it is only effective within 4.5 h...
4.
Everett J, Lermyte F, Brooks J, Tjendana-Tjhin V, Plascencia-Villa G, Hands-Portman I, et al.
Sci Adv
. 2021 Jun;
7(24).
PMID: 34108207
The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu, Cu, Fe, and Fe control key...
5.
Cabrera D, Walker K, Moise S, Telling N, Harper A
Nano Res
. 2021 Jan;
13(10):2697-2705.
PMID: 33473261
Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium concentration. Controlling these cytosolic calcium rises would provide a method to inhibit...
6.
Everett J, Brooks J, Lermyte F, OConnor P, Sadler P, Dobson J, et al.
Sci Rep
. 2020 Jun;
10(1):10332.
PMID: 32587293
Atypical low-oxidation-state iron phases in Alzheimer's disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox activity and convey toxicity. However, the origin of low-oxidation-state iron...
7.
Brooks J, Everett J, Lermyte F, Tjhin V, Banerjee S, OConnor P, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(29):11984-11991.
PMID: 32227670
A hallmark of Parkinson's disease is the death of neuromelanin-pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather...
8.
Lermyte F, Everett J, Brooks J, Bellingeri F, Billimoria K, Sadler P, et al.
Cells
. 2019 Oct;
8(10).
PMID: 31658742
Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spectrometry,...
9.
Lermyte F, Everett J, Lam Y, Wootton C, Brooks J, Barrow M, et al.
J Am Soc Mass Spectrom
. 2019 Jul;
30(10):2123-2134.
PMID: 31350722
Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have...
10.
Berry S, Walker K, Hoskins C, Telling N, Price H
Sci Rep
. 2019 Feb;
9(1):1059.
PMID: 30705309
Cutaneous leishmaniasis is a neglected tropical disease characterized by disfiguring skin lesions. Current chemotherapeutic options depend on toxic, expensive drugs that are both difficult to administer and becoming less effective...