Peter B OConnor
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Explore the profile of Peter B OConnor including associated specialties, affiliations and a list of published articles.
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Articles
143
Citations
2039
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Recent Articles
1.
Littlejohn C, Li M, Lam P, Barrow M, OConnor P
J Am Soc Mass Spectrom
. 2024 Oct;
35(12):2984-2992.
PMID: 39454130
Two-dimensional mass spectrometry (2DMS) is a truly data-independent acquisition technique used in the analysis of complex mixtures; however, the nature of the noise within these spectra is not well understood....
2.
Rahman M, Marzullo B, Lam P, Barrow M, Holman S, Ray A, et al.
Analyst
. 2024 Aug;
149(18):4687-4701.
PMID: 39101388
Antisense oligonucleotides (ASOs) are crucial for biological applications as they bind to complementary RNA sequences, modulating protein expression. ASOs undergo synthetic modifications like phosphorothioate (PS) backbone and locked nucleic acid...
3.
Everett J, Brooks J, Tjhin V, Lermyte F, Hands-Portman I, Plascencia-Villa G, et al.
ACS Chem Neurosci
. 2024 Mar;
15(7):1469-1483.
PMID: 38501754
The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer's disease. Altered metabolism of essential biometals is another feature of Alzheimer's, with amyloid plaques representing...
4.
Rahman M, Marzullo B, Holman S, Barrow M, Ray A, OConnor P
J Am Soc Mass Spectrom
. 2024 Jan;
35(2):285-299.
PMID: 38197777
Proteolysis targeting chimeras (PROTACs) are specialized molecules that bind to a target protein and a ubiquitin ligase to facilitate protein degradation. Despite their significance, native PROTACs have not undergone tandem...
5.
Letourneau D, Marzullo B, Alexandridou A, Barrow M, OConnor P, Volmer D
Anal Bioanal Chem
. 2023 Sep;
415(27):6663-6675.
PMID: 37714972
Sample preparation of complex, natural mixtures such as lignin prior to mass spectrometry analysis, however minimal, is a critical step in ensuring accurate and interference-free results. Modern shotgun-MS techniques, where...
6.
In Silico Demonstration of Two-Dimensional Mass Spectrometry Using Spatially Dependent Fragmentation
Littlejohn C, Li M, OConnor P
J Am Soc Mass Spectrom
. 2023 Feb;
34(3):409-416.
PMID: 36744747
Two-dimensional mass spectrometry (2DMS) allows for the analysis of complex mixtures of all kinds at high speed and resolution without data loss from isolation or biased acquisition, effectively generating tandem...
7.
Theisen A, Wootton C, Haris A, Morgan T, Lam Y, Barrow M, et al.
Anal Chem
. 2022 Nov;
94(45):15631-15638.
PMID: 36317856
Ultraviolet photodissociation is a fast, photon-mediated fragmentation method that yields high sequence coverage and informative cleavages of biomolecules. In this work, 193 nm UVPD was coupled with a 12 Tesla...
8.
Morgan T, Floyd T, Marzullo B, Wootton C, Barrow M, Bristow A, et al.
Polym Chem
. 2022 Aug;
13(28):4162-4169.
PMID: 35923808
Understanding modification of synthetic polymer structures is necessary for their accurate synthesis and potential applications. In this contribution, a series of partially hydrolyzed poly(2-oxazoline) species were produced forming poly[(2-polyoxazoline)--(ethylenimine)] (P(EtOx--EI))...
9.
Xu J, Li M, Marzullo B, Wootton C, Barrow M, OConnor P
J Am Soc Mass Spectrom
. 2022 Jun;
33(8):1499-1509.
PMID: 35763614
The fine structure of isotopic peak distributions of glutathione in mass spectra is measured using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at 12 and 15 T magnetic...
10.
Paris J, Theisen A, Marzullo B, Haris A, Morgan T, Barrow M, et al.
J Am Soc Mass Spectrom
. 2022 May;
33(7):1126-1133.
PMID: 35604791
Collisionally activated dissociation (CAD), infrared multiphoton dissociation (IRMPD), ultraviolet photodissociation (UVPD), electron capture dissociation and electron detachment dissociation (EDD) experiments were conducted on a set of phosphopeptides, in a Fourier...