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Neil Benson

Explore the profile of Neil Benson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 24
Citations 284
Followers 0
Related Specialties
Pharmacology
Biology
Biochemistry
Top 10 Co-Authors
Piet H van der Graaf
Hannah M Jones
Lambertus A Peletier
Jaiessh K Rawal
Stephen J Wilkinson
Helen F Boyd
Dirk Winkler
Cesar Pichardo-Almarza
Oleg V Demin
Marjoleen Nijsen
Published In
J Biomol Screen
J Theor Biol
CPT Pharmacometrics Syst Pharmacol
Eur J Cancer
Br J Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins
Kierzek A, Hickling T, Figueroa I, Kalvass J, Nijsen M, Mohan K, et al.
CPT Pharmacometrics Syst Pharmacol . 2019 Sep; 8(11):773-776. PMID: 31529677
No abstract available.
2.
First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity
Postel-Vinay S, Herbschleb K, Massard C, Woodcock V, Soria J, Walter A, et al.
Eur J Cancer . 2019 Feb; 109:103-110. PMID: 30711772
Background: Bromodomain and extraterminal motif (BET) protein inhibition is a promising cancer treatment strategy, notably for targeting MYC- or BRD4-driven diseases. A first-in-human study investigated the safety, pharmacokinetics, maximum tolerated...
3.
Quantitative Systems Pharmacology and Empirical Models: Friends or Foes?
Benson N
CPT Pharmacometrics Syst Pharmacol . 2018 Nov; 8(3):135-137. PMID: 30474925
No abstract available.
4.
Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option
Clausznitzer D, Pichardo-Almarza C, Relo A, van Bergeijk J, van der Kam E, Laplanche L, et al.
CPT Pharmacometrics Syst Pharmacol . 2018 Sep; 7(11):759-770. PMID: 30207429
Alzheimer disease (AD) is a devastating neurodegenerative disorder with high unmet medical need. Drug development is hampered by limited understanding of the disease and its driving factors. Quantitative Systems Pharmacology...
5.
The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials
van der Graaf P, Benson N
Clin Pharmacol Ther . 2018 Jun; 104(5):797. PMID: 29943816
No abstract available.
6.
Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways
Benson N, van der Graaf P, Peletier L
Eur J Pharm Sci . 2017 May; 109S:S140-S148. PMID: 28549678
A key element of the drug discovery process is target selection. Although the topic is subject to much discussion and experimental effort, there are no defined quantitative rules around optimal...
7.
Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is
Benson N
Drug Discov Today Technol . 2015 Oct; 15:41-8. PMID: 26464089
Phase II attrition remains the most important challenge for drug discovery. Tackling the problem requires improved understanding of the complexity of disease biology. Systems biology approaches to this problem can,...
8.
Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis
Vinogradova S, Zhudenkov K, Benson N, van der Graaf P, Demin O, Karelina T
J Theor Biol . 2015 Jul; 382:91-8. PMID: 26163367
Mathematical models have been widely used for understanding the dynamics of the hepatitis C virus (HCV). We propose a method to predict final clinical outcome for 24 HIV-HCV - coinfected...
9.
The rise of systems pharmacology in drug discovery and development
Benson N, van der Graaf P
Future Med Chem . 2014 Jul; 6(16):1731-4. PMID: 25066637
No abstract available.
10.
Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology
Benson N, Matsuura T, Smirnov S, Demin O, Jones H, Dua P, et al.
Interface Focus . 2014 Jan; 3(2):20120071. PMID: 24427523
The nerve growth factor (NGF) pathway is of great interest as a potential source of drug targets, for example in the management of certain types of pain. However, selecting targets...