Ned J C Lamb
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Explore the profile of Ned J C Lamb including associated specialties, affiliations and a list of published articles.
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10
Citations
277
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Recent Articles
1.
Mitutsova V, Yeo W, Davaze R, Franckhauser C, Hani E, Abdullah S, et al.
Stem Cell Res Ther
. 2017 Apr;
8(1):86.
PMID: 28420418
Background: Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the...
2.
Franckhauser C, Fernandez A, Lamb N
Biochimie
. 2013 Apr;
95(7):1450-61.
PMID: 23567337
We describe a reliable and efficient method for the purification of catalytically active and mutant inactive full-length forms of the human dual specificity phosphatase cdc25C from bacteria. The protocol involves...
3.
Franckhauser C, Mamaeva D, Heron-Milhavet L, Fernandez A, Lamb N
PLoS One
. 2010 Jul;
5(7):e11798.
PMID: 20668692
Background: The dual specificity phosphatase cdc25C was the first human cdc25 family member found to be essential in the activation of cdk1/cyclin B1 that takes place at the entry into...
4.
Heron-Milhavet L, Mamaeva D, Rochat A, Lamb N, Fernandez A
J Cell Physiol
. 2007 Jun;
214(1):158-65.
PMID: 17565718
Akt1 and Akt2 are the major isoforms of Akt expressed in muscle cells and muscle tissue. We have performed siRNA silencing of Akt1 and Akt2 in C2 myoblasts to characterize...
5.
Heron-Milhavet L, Franckhauser C, Rana V, Berthenet C, Fisher D, Hemmings B, et al.
Mol Cell Biol
. 2006 Sep;
26(22):8267-80.
PMID: 16982699
Protein kinase B (PKB/Akt) is an important modulator of insulin signaling, cell proliferation, and survival. Using small interfering RNA duplexes in nontransformed mammalian cells, we show that only Akt1 is...
6.
Wood D, Nye J, Lamb N, Fernandez A, Kitzmann M
J Biol Chem
. 2004 Dec;
280(8):6663-8.
PMID: 15613480
Mutations in genes encoding presenilins (PS1 and PS2) are responsible for the majority of early onset familial Alzheimer's disease. PS, a critical component of gamma-secretase, is responsible for the intramembranous...
7.
Rochat A, Fernandez A, Vandromme M, Moles J, Bouschet T, Carnac G, et al.
Mol Biol Cell
. 2004 Jul;
15(10):4544-55.
PMID: 15282335
During ex vivo myoblast differentiation, a pool of quiescent mononucleated myoblasts, reserve cells, arise alongside myotubes. Insulin/insulin-like growth factor (IGF) and PKB/Akt-dependent phosphorylation activates skeletal muscle differentiation and hypertrophy. We...
8.
Turowski P, Franckhauser C, Morris M, Vaglio P, Fernandez A, Lamb N
Mol Biol Cell
. 2003 Jul;
14(7):2984-98.
PMID: 12857880
In view of the common regulatory mechanism that induces transcription of the mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for...
9.
Nekhai S, Zhou M, Fernandez A, Lane W, Lamb N, Brady J, et al.
Biochem J
. 2002 Jun;
364(Pt 3):649-57.
PMID: 12049628
HIV-1 gene expression is regulated by a viral transactivator protein (Tat) which induces transcriptional elongation of HIV-1 long tandem repeat (LTR). This induction requires hyperphosphorylation of the C-terminal domain (CTD)...
10.
Pellegrin P, Fernandez A, Lamb N, Bennes R
Mol Biol Cell
. 2002 Feb;
13(2):570-8.
PMID: 11854413
The process through which macromolecules penetrate the plasma membrane of mammalian cells remains poorly defined. We have examined whether natural cellular events modulate the capacity of cells to take up...