Neali Armstrong
Overview
Explore the profile of Neali Armstrong including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
720
Followers
0
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Recent Articles
1.
OCarroll S, Peace C, Toller-Kawahisa J, Min Y, Hooftman A, Charki S, et al.
Nat Metab
. 2024 Dec;
7(1):228.
PMID: 39668260
No abstract available.
2.
OCarroll S, Peace C, Toller-Kawahisa J, Min Y, Hooftman A, Charki S, et al.
Nat Metab
. 2024 Oct;
6(11):2060-2069.
PMID: 39406969
Itaconate is one of the most highly upregulated metabolites in inflammatory macrophages and has been shown to have immunomodulatory properties. Here, we show that itaconate promotes type I interferon production...
3.
Armstrong N, Storey C, Noll S, Margulis K, Soe M, Xu H, et al.
Cell Rep
. 2022 Mar;
38(9):110453.
PMID: 35235785
Inherited pathogenic succinate dehydrogenase (SDHx) gene mutations cause the hereditary pheochromocytoma and paraganglioma tumor syndrome. Syndromic tumors exhibit elevated succinate, an oncometabolite that is proposed to drive tumorigenesis via DNA...
4.
Armstrong N, Jasti J, Beich-Frandsen M, Gouaux E
Cell
. 2006 Oct;
127(1):85-97.
PMID: 17018279
The canonical conformational states occupied by most ligand-gated ion channels, and many cell-surface receptors, are the resting, activated, and desensitized states. While the resting and activated states of multiple receptors...
5.
Robert A, Armstrong N, Gouaux J, Howe J
J Neurosci
. 2005 Apr;
25(15):3752-62.
PMID: 15829627
Glutamate binds to AMPA receptors within a deep cleft between two globular protein domains (domains 1 and 2). Once glutamate binds, the cleft closes, and agonist-bound structures of the isolated...
6.
Madden D, Armstrong N, Svergun D, Perez J, Vachette P
J Biol Chem
. 2005 Mar;
280(25):23637-42.
PMID: 15755731
Agonist-induced conformational changes in the ligand-binding domains (LBD) of glutamate receptor ion channels provide the driving force for molecular rearrangements that mediate channel opening and subsequent desensitization. The resulting regulated...
7.
Mayer M, Armstrong N
Annu Rev Physiol
. 2004 Feb;
66:161-81.
PMID: 14977400
A vast number of proteins are involved in synaptic function. Many have been cloned and their functional role defined with varying degrees of success, but their number and complexity currently...
8.
Armstrong N, Mayer M, Gouaux E
Proc Natl Acad Sci U S A
. 2003 May;
100(10):5736-41.
PMID: 12730367
The (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazole) propionic acid (AMPA) receptor discriminates between agonists in terms of binding and channel gating; AMPA is a high-affinity full agonist, whereas kainate is a low-affinity partial agonist. Although...
9.
Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E
Nature
. 2002 May;
417(6886):245-53.
PMID: 12015593
Ligand-gated ion channels transduce chemical signals into electrical impulses by opening a transmembrane pore in response to binding one or more neurotransmitter molecules. After activation, many ligand-gated ion channels enter...