Nayan Jain
Overview
Explore the profile of Nayan Jain including associated specialties, affiliations and a list of published articles.
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14
Citations
118
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Recent Articles
1.
Perica K, Jain N, Scordo M, Patel R, Eren O, Patel U, et al.
N Engl J Med
. 2025 Feb;
392(6):577-583.
PMID: 39908432
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of...
2.
Dobrin A, Lindenbergh P, Shi Y, Perica K, Xie H, Jain N, et al.
Nat Cancer
. 2024 Mar;
5(5):760-773.
PMID: 38503896
Chimeric antigen receptor T cells have dramatically improved the treatment of hematologic malignancies. T cell antigen receptor (TCR)-based cell therapies are yet to achieve comparable outcomes. Importantly, chimeric antigen receptors...
3.
Jain N, Zhao Z, Koche R, Antelope C, Gozlan Y, Montalbano A, et al.
Cancer Discov
. 2023 Nov;
14(1):142-157.
PMID: 37934007
Significance: T cells engineered with CD28-based CARs possess robust effector function and antigen sensitivity but are hampered by limited persistence, which may result in tumor relapse. We report an epigenetic...
4.
Jain N, Zhao Z, Feucht J, Koche R, Iyer A, Dobrin A, et al.
Nature
. 2023 Feb;
615(7951):315-322.
PMID: 36755094
Further advances in cell engineering are needed to increase the efficacy of chimeric antigen receptor (CAR) and other T cell-based therapies. As T cell differentiation and functional states are associated...
5.
Bhadresha K, Upadhyay V, Brahmbhatt J, Mughal M, Jain N, Rawal R
Sci Rep
. 2022 Nov;
12(1):20258.
PMID: 36424413
Lung cancer progression is often driven by metastasis, which has resulted in a considerable increase in lung cancer-related deaths. Cell-derived extracellular vesicles (EVs), particularly exosomes, serve key roles in cellular...
6.
Bijani S, Shaikh F, Mirza S, Siu S, Jain N, Rawal R, et al.
ACS Omega
. 2022 May;
7(19):16278-16287.
PMID: 35601326
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared...
7.
Bhadresha K, Kumar S, Brahmbhatt J, Patel C, Pandya P, Jain N, et al.
Chem Biol Interact
. 2021 Dec;
353:109774.
PMID: 34958756
Poor prognosis and metastasis have been recognized as the major cause of breast cancer related deaths worldwide. Recent experimental evidence has shown that Hsp90, the prime chaperone, is overexpressed in...
8.
Bhadresha K, Patel M, Brahmbhatt J, Jain N, Rawal R
Nutr Cancer
. 2021 Nov;
74(7):2522-2539.
PMID: 34751606
is a medicinally important plant that has various medical and nutritional uses. Plant miRNAs are a class of non-coding endogenous small RNAs that regulate human-specific mRNA but the mechanistic actions...
9.
Bhadresha K, Upadhyay V, Kumar S, Pandya P, Jain N, Rawal R
J Biomol Struct Dyn
. 2021 Oct;
40(24):13675-13681.
PMID: 34693877
Heat shock protein 90 (Hsp90) is the prime molecular chaperone found to be overexpressed in cancer cells and pose as an anti-cancer therapeutic drug target for cancer chemotherapy. Even drugs...
10.
Friedman D, Goldberg J, Molinsky R, Hanson M, Castano A, Raza S, et al.
JMIR Cardio
. 2021 Jun;
5(1):e29101.
PMID: 34061037
Background: Patients with heart failure (HF) in skilled nursing facilities (SNFs) have 30-day hospital readmission rates as high as 43%. A virtual cardiovascular care program, consisting of patient selection, initial...