Nathaniel S Linde
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Explore the profile of Nathaniel S Linde including associated specialties, affiliations and a list of published articles.
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8
Citations
117
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Recent Articles
1.
Demirci S, Zeng J, Palchaudhuri R, Wu C, Abraham D, Hayal T, et al.
Cell Stem Cell
. 2024 Dec;
32(2):209-226.e8.
PMID: 39642886
Editing the +58 region of the BCL11A erythroid enhancer has shown promise in treating β-globin disorders. To address variations in fetal hemoglobin (HbF) response, we investigated editing both +58 and ...
2.
Essawi K, Hakami W, Khan M, Martin R, Zeng J, Chu R, et al.
Mol Ther Methods Clin Dev
. 2023 Jun;
29:483-493.
PMID: 37273902
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from (SpCas9) and (SaCas9) in...
3.
Peslak S, Demirci S, Chandra V, Ryu B, Bhardwaj S, Jiang J, et al.
Mol Ther Nucleic Acids
. 2023 Feb;
31:452-465.
PMID: 36852088
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type () and adult-type...
4.
Demirci S, Zeng J, Wu Y, Uchida N, Shen A, Pellin D, et al.
J Clin Invest
. 2020 Sep;
130(12):6677-6687.
PMID: 32897878
Gene editing of the erythroid-specific BCL11A enhancer in hematopoietic stem and progenitor cells (HSPCs) from patients with sickle cell disease (SCD) induces fetal hemoglobin (HbF) without detectable toxicity, as assessed...
5.
Demirci S, Mora J, Yapundich M, Drysdale C, Gamer J, Nassehi T, et al.
Exp Hematol
. 2019 Jun;
75:21-25.e1.
PMID: 31173819
Elevated fetal hemoglobin (HbF) is associated with reduced severity of sickle cell disease. Therefore, γ-globin protein levels and F-cell (HbF-positive red blood cell) percentages are used for estimation of clinical...
6.
Yun N, Linde N, Dziuba N, Zacks M, Smith J, Smith J, et al.
Am J Trop Med Hyg
. 2008 Aug;
79(2):275-82.
PMID: 18689636
Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the...
7.
Kendirgi F, Yun N, Linde N, Zacks M, Smith J, Smith J, et al.
Hum Vaccin
. 2008 Apr;
4(6):410-9.
PMID: 18443425
Vaccine development for possible influenza pandemics has been challenging. Conventional vaccines such as inactivated and live attenuated virus preparations are limited in terms of production speed and capacity. DNA vaccination...
8.
Yun N, Linde N, Zacks M, Barr I, Hurt A, Smith J, et al.
Virology
. 2008 Feb;
374(1):198-209.
PMID: 18234269
The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated...