Nathaniel J Traaseth
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Explore the profile of Nathaniel J Traaseth including associated specialties, affiliations and a list of published articles.
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61
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1634
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Recent Articles
1.
Xie P, Li Y, Lamon G, Kuang H, Wang D, Traaseth N
Nat Commun
. 2025 Jan;
16(1):7.
PMID: 39746942
Advancements in cryo-EM have stimulated a revolution in structural biology. Yet, for membrane proteins near the cryo-EM size threshold of approximately 40 kDa, including transporters and G-protein coupled receptors, the...
2.
Li J, Her A, Besch A, Ramirez-Cordero B, Crames M, Banigan J, et al.
Nat Commun
. 2024 May;
15(1):4537.
PMID: 38806470
The multidrug efflux transporter EmrE from Escherichia coli requires anionic residues in the substrate binding pocket for coupling drug transport with the proton motive force. Here, we show how protonation...
3.
Li J, Li Y, Koide A, Kuang H, Torres V, Koide S, et al.
Nat Commun
. 2024 May;
15(1):4494.
PMID: 38802368
Efflux pump antiporters confer drug resistance to bacteria by coupling proton import with the expulsion of antibiotics from the cytoplasm. Despite efforts there remains a lack of understanding as to...
4.
Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state
Besch A, Marsiglia W, Mohammadi M, Zhang Y, Traaseth N
Proc Natl Acad Sci U S A
. 2023 Feb;
120(8):e2213090120.
PMID: 36791110
Many types of human cancers are being treated with small molecule ATP-competitive inhibitors targeting the kinase domain of receptor tyrosine kinases. Despite initial successful remission, long-term treatment almost inevitably leads...
5.
Wallon L, Khan I, Teng K, Koide A, Zuberi M, Li J, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2204481119.
PMID: 36252024
RAS mutants are major therapeutic targets in oncology with few efficacious direct inhibitors available. The identification of a shallow pocket near the Switch II region on RAS has led to...
6.
Jiang L, Zuo X, Li J, Traaseth N, Kirshenbaum K
Angew Chem Int Ed Engl
. 2022 Apr;
61(27):e202201895.
PMID: 35415953
Despite recent progress, it remains challenging to program biomacromolecules to assemble into discrete nanostructures with pre-determined sizes and topologies. We report here a novel strategy to address this challenge. By...
7.
Brawley D, Sauer D, Li J, Zheng X, Koide A, Jedhe G, et al.
Nat Chem Biol
. 2022 Apr;
18(7):706-712.
PMID: 35361990
Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct compounds and lowering their intracellular concentration. Yet, there are no clinically approved drugs to inhibit efflux pumps, which would...
8.
Li J, Her A, Traaseth N
Proc Natl Acad Sci U S A
. 2021 Oct;
118(41).
PMID: 34607959
EmrE is an multidrug efflux pump and member of the small multidrug resistance (SMR) family that transports drugs as a homodimer by harnessing energy from the proton motive force. SMR...
9.
Marsiglia W, Qamra R, Jackson K, Traaseth N
J Chem Educ
. 2021 Jul;
97(2):437-442.
PMID: 34290452
Design of undergraduate laboratory courses that provide meaningful research-based experiences enhance undergraduate curricula and prepare future graduate students for research careers. In this article, a Course-based Undergraduate Research Experience (CURE)...
10.
Li J, Her A, Traaseth N
J Biomol NMR
. 2020 Jun;
74(6-7):355-363.
PMID: 32514875
NMR spectroscopy is commonly used to infer site-specific acid dissociation constants (pK) since the chemical shift is sensitive to the protonation state. Methods that probe atoms nearest to the functional...