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Nathan M Holmes

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Articles 56
Citations 444
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Recent Articles
1.
Hill T, Holmes N, Clemens K
Neurobiol Learn Mem . 2025 Jan; 217:108020. PMID: 39793882
Humans and animals use information about future access to rewards to influence their behaviour in the present, however the evidence for this is largely anecdotal. Here we use the nicotine...
2.
Kennedy N, Lee J, Killcross S, Westbrook R, Holmes N
Elife . 2024 Jul; 13. PMID: 39027985
How is new information organized in memory? According to latent state theories, this is determined by the level of surprise, or prediction error, generated by the new information: a small...
3.
Chan Y, Lee J, Fam J, Westbrook R, Holmes N
J Exp Psychol Anim Learn Cogn . 2024 Apr; 50(2):77-98. PMID: 38587939
Rescorla (2000, 2001) interpreted his compound test results to show that both common and individual error terms regulate associative change such that the element of a conditioned compound with the...
4.
Bouchekioua Y, Craddock P, Holmes N
Psychol Rev . 2024 Feb; 131(4):952-965. PMID: 38300570
Pavlovian conditioning is widely used to study the substrates of learning and memory in the mammalian brain. In a standard protocol, subjects are exposed to pairings of a conditioned stimulus...
5.
Leake J, Cardona L, Mencevski F, Westbrook R, Holmes N
J Neurosci . 2024 Jan; 44(9). PMID: 38286626
It is widely accepted that fear memories are consolidated through protein synthesis-dependent changes in the basolateral amygdala complex (BLA). However, recent studies show that protein synthesis is required to consolidate...
6.
Kennedy N, Holmes N, Peng L, Westbrook R
Neurobiol Learn Mem . 2023 Dec; 207:107879. PMID: 38081536
This series of experiments examined the effects of extinction and an explicitly unpaired treatment on the ability of a conditioned stimulus (CS) to function as a reinforcer. Rats were trained...
7.
Leake J, Leidl D, Lay B, Fam J, Giles M, Qureshi O, et al.
J Neurosci . 2023 Nov; 44(2). PMID: 37963767
Activity in the basolateral amygdala complex (BLA) is needed to encode fears acquired through contact with both innate sources of danger (i.e., things that are painful) and learned sources of...
8.
Keidar T, Williams-Spooner M, Wong F, Westbrook R, Holmes N
J Neurosci . 2023 Aug; 43(39):6679-6696. PMID: 37607821
It is widely accepted that Pavlovian fear conditioning requires activation of NMDA receptors (NMDARs) in the basolateral amygdala complex (BLA). However, it was recently shown that activation of NMDAR in...
9.
Qureshi O, Leake J, Delaney A, Killcross S, Westbrook R, Holmes N
J Neurosci . 2023 Mar; 43(16):2934-2949. PMID: 36927572
This study examined the effect of danger on consolidation of neutral information in two regions of the rat (male and female) medial temporal lobe: the perirhinal cortex (PRh) and basolateral...
10.
Todd T, Holmes N
Front Behav Neurosci . 2022 Oct; 16:954646. PMID: 36311862
In standard (first-order) Pavlovian conditioning protocols, pairings of an initially neutral conditioned stimulus (CS) and a biologically significant unconditioned stimulus (US) result in the formation of a CS-US association. The...