Nathan G Hedrick
Overview
Explore the profile of Nathan G Hedrick including associated specialties, affiliations and a list of published articles.
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13
Citations
563
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Recent Articles
1.
Hattori R, Hedrick N, Jain A, Chen S, You H, Hattori M, et al.
Nat Neurosci
. 2024 Jul;
27(8):1632.
PMID: 38956167
No abstract available.
2.
Hedrick N, Wright W, Komiyama T
Sci Adv
. 2024 Mar;
10(11):eadk0540.
PMID: 38489360
During learning, synaptic connections between excitatory neurons in the brain display considerable dynamism, with new connections being added and old connections eliminated. Synapse elimination offers an opportunity to understand the...
3.
Dunton K, Hedrick N, Meamardoost S, Ren C, Howe J, Wang J, et al.
J Neurosci
. 2024 Jan;
44(10).
PMID: 38238073
Experience-dependent gene expression reshapes neural circuits, permitting the learning of knowledge and skills. Most learning involves repetitive experiences during which neurons undergo multiple stages of functional and structural plasticity. Currently,...
4.
Hattori R, Hedrick N, Jain A, Chen S, You H, Hattori M, et al.
Nat Neurosci
. 2023 Nov;
26(12):2182-2191.
PMID: 37957318
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple timescales, has been successful in training deep RL models that generalize to new environments. It has been hypothesized that the...
5.
Hedrick N, Lu Z, Bushong E, Singhi S, Nguyen P, Magana Y, et al.
Nat Neurosci
. 2022 Jun;
25(6):726-737.
PMID: 35654957
Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging and correlated electron...
6.
Chen L, Lyons M, Liu F, Green M, Hedrick N, Williams A, et al.
J Biol Chem
. 2020 May;
295(25):8613-8627.
PMID: 32393578
-Methyl-d-aspartate type glutamate receptors (NMDARs) are key mediators of synaptic activity-regulated gene transcription in neurons, both during development and in the adult brain. Developmental differences in the glutamate receptor ionotropic...
7.
Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick N, Agnello E, et al.
Neuron
. 2019 May;
102(6):1199-1210.e6.
PMID: 31078368
Long-term synaptic plasticity requires a mechanism that converts short Ca pulses into persistent biochemical signaling to maintain changes in the synaptic structure and function. Here, we present a novel mechanism...
8.
Martyn A, Toth K, Schmalzigaug R, Hedrick N, Rodriguiz R, Yasuda R, et al.
PLoS One
. 2018 Mar;
13(3):e0194350.
PMID: 29554125
The signaling scaffold protein GIT1 is expressed widely throughout the brain, but its function in vivo remains elusive. Mice lacking GIT1 have been proposed as a model for attention deficit-hyperactivity...
9.
Hedrick N, Yasuda R
Curr Opin Neurobiol
. 2017 Jul;
45:193-201.
PMID: 28709063
While it is generally appreciated that learning involves the structural rearrangement of neuronal circuits, the underlying orchestration of molecular events that drives these changes is not as well understood. Recent...
10.
Peters A, Lee J, Hedrick N, ONeil K, Komiyama T
Nat Neurosci
. 2017 Jul;
20(8):1133-1141.
PMID: 28671694
Motor learning is accompanied by widespread changes within the motor cortex, but it is unknown whether these changes are ultimately funneled through a stable corticospinal output channel or whether the...