Nathan D Dees
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Explore the profile of Nathan D Dees including associated specialties, affiliations and a list of published articles.
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10
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2042
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Recent Articles
1.
Sung H, Kanchi K, Wang X, Hill K, Messina J, Lee J, et al.
Oncotarget
. 2016 Mar;
7(17):23885-96.
PMID: 26993606
Inactivation of Ras GTPase activating proteins (RasGAPs) can activate Ras, increasing the risk for tumor development. Utilizing a melanoma whole genome sequencing (WGS) data from 13 patients, we identified two...
2.
Griffith M, Griffith O, Smith S, Ramu A, Callaway M, Brummett A, et al.
PLoS Comput Biol
. 2015 Jul;
11(7):e1004274.
PMID: 26158448
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides...
3.
Ding L, Kim M, Kanchi K, Dees N, Lu C, Griffith M, et al.
PLoS One
. 2014 Nov;
9(11):e111153.
PMID: 25393105
To reveal the clonal architecture of melanoma and associated driver mutations, whole genome sequencing (WGS) and targeted extension sequencing were used to characterize 124 melanoma cases. Significantly mutated gene analysis...
4.
Miller C, White B, Dees N, Griffith M, Welch J, Griffith O, et al.
PLoS Comput Biol
. 2014 Aug;
10(8):e1003665.
PMID: 25102416
The sensitivity of massively-parallel sequencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells harboring distinct mutations. A fine resolution view of this clonal architecture provides insight...
5.
Govindan R, Ding L, Griffith M, Subramanian J, Dees N, Kanchi K, et al.
Cell
. 2012 Sep;
150(6):1121-34.
PMID: 22980976
We report the results of whole-genome and transcriptome sequencing of tumor and adjacent normal tissue samples from 17 patients with non-small cell lung carcinoma (NSCLC). We identified 3,726 point mutations...
6.
Dees N, Zhang Q, Kandoth C, Wendl M, Schierding W, Koboldt D, et al.
Genome Res
. 2012 Jul;
22(8):1589-98.
PMID: 22759861
Massively parallel sequencing technology and the associated rapidly decreasing sequencing costs have enabled systemic analyses of somatic mutations in large cohorts of cancer cases. Here we introduce a comprehensive mutational...
7.
Dees N, Bahar S
PLoS One
. 2010 Aug;
5(8):e11952.
PMID: 20689827
The role of mutation rate in optimizing key features of evolutionary dynamics has recently been investigated in various computational models. Here, we address the related question of how maximum mutation...
8.
Ding L, Ellis M, Li S, Larson D, Chen K, Wallis J, et al.
Nature
. 2010 Apr;
464(7291):999-1005.
PMID: 20393555
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples...
9.
Dees N, Bahar S, Moss F
Phys Biol
. 2008 Nov;
5(4):044001.
PMID: 19029598
Search strategies are currently of great interest, with reports on foraging ranging from albatrosses and spider monkeys to microzooplankton. Here, we investigate the role of noise in optimizing search strategies....
10.
Dees N, Bahar S, Garcia R, Moss F
J Theor Biol
. 2008 Mar;
252(1):69-76.
PMID: 18343411
We explore the variability that animals display in their movement choices as they forage in a finite-sized food patch with a uniform food distribution, and present a framework for how...