Nathalie Kanda
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Explore the profile of Nathalie Kanda including associated specialties, affiliations and a list of published articles.
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10
Citations
209
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Recent Articles
1.
Ma L, Ge Y, Brown J, Choi S, Elshikha A, Kanda N, et al.
bioRxiv
. 2024 Jan;
PMID: 38293097
Tryptophan modulates disease activity and the composition of microbiota in the B6. (TC) mouse model of lupus. To directly test the effect of tryptophan on the gut microbiome, we transplanted...
2.
Elshikha A, Ge Y, Brown J, Kanda N, Zadeh M, Abboud G, et al.
iScience
. 2023 Jul;
26(7):107122.
PMID: 37416482
Gut dysbiosis has been associated with lupus pathogenesis, and fecal microbiota transfers (FMT) from lupus-prone mice shown to induce autoimmune activation into healthy mice. The immune cells of lupus patients...
3.
Abboud G, Choi S, Zhang X, Park Y, Kanda N, Zeumer-Spataro L, et al.
J Immunol
. 2023 Jan;
210(4):377-388.
PMID: 36602759
The activation of lymphocytes in patients with lupus and in mouse models of the disease is coupled with an increased cellular metabolism in which glucose plays a major role. The...
4.
Elshikha A, Teng X, Kanda N, Li W, Choi S, Abboud G, et al.
Front Immunol
. 2022 Jul;
13:914468.
PMID: 35860280
We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6. (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed...
5.
Brown J, Abboud G, Ma L, Choi S, Kanda N, Zeumer-Spataro L, et al.
iScience
. 2022 May;
25(5):104241.
PMID: 35494242
A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell...
6.
Choi S, Li W, Zhang X, Kanda N, Zeumer-Spataro L, Teng X, et al.
J Immunol
. 2022 Apr;
208(9):2098-2108.
PMID: 35387839
Several studies have shown an enhanced metabolism in the CD4 T cells of lupus patients and lupus-prone mice. Little is known about the metabolism of B cells in lupus. In...
7.
Abboud G, Elshikha A, Kanda N, Zeumer-Spataro L, Morel L
J Immunol
. 2022 Feb;
208(5):1066-1075.
PMID: 35140132
BATF3-deficient mice that lack CD8 dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the lupus-suppressive...
8.
Li W, Gong M, Park Y, Elshikha A, Choi S, Brown J, et al.
JCI Insight
. 2021 Jun;
6(14).
PMID: 34156979
Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. Esrrg deficiency impaired the maintenance...
9.
Abboud G, Choi S, Kanda N, Zeumer-Spataro L, Roopenian D, Morel L
Front Immunol
. 2018 Sep;
9:1973.
PMID: 30233578
The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic CD4 T cells from the KRN strain that are activated by glucose-6-phosphate isomerase (GPI) peptides...
10.
Yin Y, Choi S, Xu Z, Zeumer L, Kanda N, Croker B, et al.
J Immunol
. 2015 Nov;
196(1):80-90.
PMID: 26608911
We have previously shown that CD4(+) T cells from B6.Sle1Sle2.Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-D-glucose, which inhibits glucose metabolism, and metformin,...