Ahmed S Elshikha
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Explore the profile of Ahmed S Elshikha including associated specialties, affiliations and a list of published articles.
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18
Citations
179
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Recent Articles
1.
Elshikha A, Abboud G, Avdiaj R, Morel L, Song S
Biomolecules
. 2025 Jan;
15(1).
PMID: 39858436
Endosomal toll-like receptors (TLRs) TLR7, TLR8, and TLR9 play an important role in systemic lupus erythematosus (SLE) pathogenesis. The proteolytic processing of these receptors in the endolysosome is required for...
2.
Elshikha A, Ge Y, Brown J, Kanda N, Zadeh M, Abboud G, et al.
iScience
. 2023 Jul;
26(7):107122.
PMID: 37416482
Gut dysbiosis has been associated with lupus pathogenesis, and fecal microbiota transfers (FMT) from lupus-prone mice shown to induce autoimmune activation into healthy mice. The immune cells of lupus patients...
3.
Gong M, Choi S, Park Y, Zou X, Elshikha A, Gerriets V, et al.
iScience
. 2023 May;
26(5):106774.
PMID: 37216123
The expansion of follicular helper T (Tfh) cells, which is tightly associated with the development of lupus, is reversed by the inhibition of either glycolysis or glutaminolysis in mice. Here...
4.
Yuan Y, Van Belkum M, OBrien A, Garcia A, Troncoso K, Elshikha A, et al.
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291555
Human alpha 1 antitrypsin (hAAT) is a multifunctional protein that has been shown to have anti-inflammatory and cellular protective properties. While previous studies demonstrated the antiaging potential of hAAT, the...
5.
Elshikha A, Teng X, Kanda N, Li W, Choi S, Abboud G, et al.
Front Immunol
. 2022 Jul;
13:914468.
PMID: 35860280
We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6. (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed...
6.
Abboud G, Elshikha A, Kanda N, Zeumer-Spataro L, Morel L
J Immunol
. 2022 Feb;
208(5):1066-1075.
PMID: 35140132
BATF3-deficient mice that lack CD8 dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the lupus-suppressive...
7.
Li W, Gong M, Park Y, Elshikha A, Choi S, Brown J, et al.
JCI Insight
. 2021 Jun;
6(14).
PMID: 34156979
Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. Esrrg deficiency impaired the maintenance...
8.
Cornaby C, Elshikha A, Teng X, Choi S, Scindia Y, Davidson A, et al.
Immunohorizons
. 2020 Jun;
4(6):319-331.
PMID: 32540987
CTLA4Ig, a reagent that inhibits CD28 signaling, has shown therapeutic efficacy in mouse models of lupus nephritis (LN) when combined with several other biologics or standard of care drugs. Unfortunately,...
9.
Li W, Elshikha A, Cornaby C, Teng X, Abboud G, Brown J, et al.
JCI Insight
. 2020 Jun;
5(11).
PMID: 32493841
Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and...
10.
Elshikha A, Abboud G, van der Meijden-Erkelens L, Lu Y, Chen M, Yuan Y, et al.
J Clin Med
. 2019 Sep;
8(9).
PMID: 31470606
Diffuse alveolar hemorrhage (DAH) is a fatal complication in patients with lupus. DAH can be induced in B6 mice by an intraperitoneal injection of pristane. Since human alpha-1-antitrypsin (hAAT) is...