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Nathalie Bernoud-Hubac

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Recent Articles
11.
Hachem M, Nacir H, Picq M, Belkouch M, Bernoud-Hubac N, Windust A, et al.
Nutrients . 2020 Jan; 12(1). PMID: 31963708
AceDoPC is a structured glycerophospholipid that targets the brain with docosahexaenoic acid (DHA) and is neuroprotective in the experimental ischemic stroke. AceDoPC is a stabilized form of the physiological 2-DHA-LysoPC...
12.
Lo Van A, Hachem M, Lagarde M, Bernoud-Hubac N
Int J Mol Sci . 2019 Sep; 20(17). PMID: 31480215
The mammalian brain is enriched with lipids that serve as energy catalyzers or secondary messengers of essential signaling pathways. Docosahexaenoic acid (DHA) is an omega-3 fatty acid synthesized de novo...
13.
Bazinet R, Bernoud-Hubac N, Lagarde M
Prostaglandins Leukot Essent Fatty Acids . 2019 Feb; 142:1-3. PMID: 30773208
The brain requires a constant supply of docosahexaenoic acid (DHA) from blood to maintain DHA levels within the brain. Several plasma pools have been proposed to supply the brain with...
14.
Page D, Labadie C, Reling P, Bott R, Garcia C, Gaillard C, et al.
Food Chem . 2018 Oct; 274:500-509. PMID: 30372971
Lycopene bioaccessibility is enhanced by processing, as explained by the destructuration of plant tissues, making diffusion easier. However, in tomato, the relationship between grinding intensity and lycopene release from purees...
15.
Van den Brink D, Cubizolle A, Chatelain G, Davoust N, Girard V, Johansen S, et al.
PLoS Genet . 2018 Sep; 14(9):e1007627. PMID: 30199545
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer's and Parkinson's diseases....
16.
Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Fourmaux B, et al.
Mol Neurobiol . 2018 Jun; 56(2):986-999. PMID: 29858775
Docosahexaenoic acid (DHA, 22:6n-3) is an essential omega-3 polyunsaturated fatty acid (PUFA) that is required for proper brain development and cerebral functions. While DHA deficiency in the brain was shown...
17.
Lagarde M, Guichardant M, Bernoud-Hubac N, Calzada C, Vericel E
Biochim Biophys Acta Mol Cell Biol Lipids . 2018 Mar; 1863(6):651-656. PMID: 29555597
The oxygenation metabolism of arachidonic acid (ArA) has been early described in blood platelets, in particular with its conversion into the potent labile thromboxane A that induces platelet aggregation and...
18.
Fourrier C, Remus-Borel J, Greenhalgh A, Guichardant M, Bernoud-Hubac N, Lagarde M, et al.
J Neuroinflammation . 2017 Aug; 14(1):170. PMID: 28838312
Background: Neuroinflammatory processes are considered a double-edged sword, having both protective and detrimental effects in the brain. Microglia, the brain's resident innate immune cells, are a key component of neuroinflammatory...
19.
Lo Van A, Fourmaux B, Picq M, Guichardant M, Lagarde M, Bernoud-Hubac N
Lipids . 2017 Aug; 52(9):751-761. PMID: 28776175
Fatty acids have many health benefits in a great variety of diseases ranging from cardiovascular to cerebral diseases. For instance, docosahexaenoic acid (DHA), which is highly enriched in brain phospholipids,...
20.
Belkouch M, Hachem M, Elgot A, Lo Van A, Picq M, Guichardant M, et al.
J Nutr Biochem . 2016 Nov; 38:1-11. PMID: 27825512
Among omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA, 22:6n-3) is important for adequate brain development and cognition. DHA is highly concentrated in the brain and plays an essential role...