Natarajan Vijayasankaran
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Explore the profile of Natarajan Vijayasankaran including associated specialties, affiliations and a list of published articles.
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12
Citations
333
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Recent Articles
1.
Effect of cell culture medium additives on color and acidic charge variants of a monoclonal antibody
Vijayasankaran N, Varma S, Yang Y, Meier S, Kiss R
Biotechnol Prog
. 2018 Jun;
34(5):1298-1307.
PMID: 29882320
This manuscript summarizes the effect of certain cell culture medium additives on antibody drug substance coloration and acidic charge variants. It has been shown previously that B-vitamins and iron in...
2.
Vijayasankaran N, Varma S, Yang Y, Mun M, Arevalo S, Gawlitzek M, et al.
Biotechnol Prog
. 2013 Jun;
29(5):1270-7.
PMID: 23804462
As the industry moves toward subcutaneous delivery as a preferred route of drug administration, high drug substance concentrations are becoming the norm for monoclonal antibodies. At such high concentrations, the...
3.
Li J, Gu W, Edmondson D, Lu C, Vijayasankaran N, Figueroa B, et al.
Biotechnol Bioeng
. 2012 Jan;
109(7):1685-92.
PMID: 22252532
NS0 cells require exogenous cholesterol for growth. The non-glutamine synthetase (GS) cholesterol-dependent NS0 host was treated with 5-azacytidine (5azaC), a demethylation drug, and adapted to grow in cholesterol-free, chemically defined...
4.
Li J, Wong C, Vijayasankaran N, Hudson T, Amanullah A
Biotechnol Bioeng
. 2011 Nov;
109(5):1173-86.
PMID: 22124879
Lactate has long been regarded as one of the key metabolites of mammalian cell cultures. High levels of lactate have clear negative impacts on cell culture processes, and therefore, a...
5.
Luo J, Vijayasankaran N, Autsen J, Santuray R, Hudson T, Amanullah A, et al.
Biotechnol Bioeng
. 2011 Oct;
109(1):146-56.
PMID: 21964570
A metabolic shift from lactate production (LP) to net lactate consumption (LC) phenotype was observed in certain Chinese hamster ovary (CHO) cell lines during the implementation of a new chemically...
6.
Yuk I, Zhang B, Yang Y, Dutina G, Leach K, Vijayasankaran N, et al.
Biotechnol Bioeng
. 2011 May;
108(11):2600-10.
PMID: 21618472
Protein glycation is a non-enzymatic glycosylation that can occur to proteins in the human body, and it is implicated in the pathogenesis of multiple chronic diseases. Glycation can also occur...
7.
Zhou M, Crawford Y, Ng D, Tung J, Pynn A, Meier A, et al.
J Biotechnol
. 2011 Mar;
153(1-2):27-34.
PMID: 21392546
Large-scale fed-batch cell culture processes of CHO cells are the standard platform for the clinical and commercial production of monoclonal antibodies. Lactate is one of the major by-products of CHO...
8.
Yu M, Hu Z, Pacis E, Vijayasankaran N, Shen A, Li F
Biotechnol Bioeng
. 2010 Dec;
108(5):1078-88.
PMID: 21165902
One of the major goals in cell culture process development for therapeutic antibody production is to develop methods to reach high titer in classical fed-batch processes. This goal is often...
9.
Li F, Vijayasankaran N, Shen A, Kiss R, Amanullah A
MAbs
. 2010 Jul;
2(5):466-79.
PMID: 20622510
Animal cell culture technology has advanced significantly over the last few decades and is now generally considered a reliable, robust and relatively mature technology. A range of biotherapeutics are currently...
10.
Vijayasankaran N, Carlson R, Srienc F
Biomacromolecules
. 2005 Mar;
6(2):604-11.
PMID: 15762620
We have constructed a tandem gene expression cassette containing three Ralstonia eutropha poly[(R)-3-hydroxybutyrate] (PHB) synthesis genes under the control of the Pichia pastoris glyceraldehyde-3-phosphate promoter and the green fluorescent protein...