Nataliia V Machushynets
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Explore the profile of Nataliia V Machushynets including associated specialties, affiliations and a list of published articles.
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6
Citations
21
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Recent Articles
1.
Machushynets N, Lysenko V, Du C, Slingerland C, Elsayed S, Liles M, et al.
Org Lett
. 2025 Mar;
PMID: 40084850
A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of spp. to identify the producers of a little-studied class of lipopeptides known as...
2.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
3.
Machushynets N, Al Ayed K, Terlouw B, Du C, Buijs N, Willemse J, et al.
ACS Chem Biol
. 2024 Apr;
19(5):1106-1115.
PMID: 38602492
The prevalence of multidrug-resistant (MDR) pathogens combined with a decline in antibiotic discovery presents a major challenge for health care. To refill the discovery pipeline, we need to find new...
4.
Nunez Santiago I, Machushynets N, Mladic M, van Bergeijk D, Elsayed S, Hankemeier T, et al.
Commun Chem
. 2024 Apr;
7(1):71.
PMID: 38561415
Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space...
5.
Al Ayed K, Zamarbide Losada D, Machushynets N, Terlouw B, Elsayed S, Schill J, et al.
ACS Infect Dis
. 2023 Mar;
9(4):739-748.
PMID: 37000899
The unabated rise of antibiotic resistance has raised the specter of a post-antibiotic era and underscored the importance of developing new classes of antibiotics. The relacidines are a recently discovered...
6.
Machushynets N, Elsayed S, Du C, Siegler M, de la Cruz M, Genilloud O, et al.
Sci Rep
. 2022 Feb;
12(1):2813.
PMID: 35181725
Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less...
7.
Machushynets N, Wu C, Elsayed S, Hankemeier T, van Wezel G
J Ind Microbiol Biotechnol
. 2019 Feb;
46(3-4):483-492.
PMID: 30729343
Actinobacteria are a major source of novel bioactive natural products. A challenge in the screening of these microorganisms lies in finding the favorable growth conditions for secondary metabolite production and...