Natalie N Kinloch
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Explore the profile of Natalie N Kinloch including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
369
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Recent Articles
1.
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Lee G, Khadka P, Gowanlock S, Copertino Jr D, Duncan M, Omondi F, et al.
Nat Commun
. 2024 Jul;
15(1):5480.
PMID: 38956017
The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males...
2.
Duncan M, Omondi F, Kinloch N, Lapointe H, Speckmaier S, Moran-Garcia N, et al.
AIDS
. 2024 Jan;
38(8):1120-1130.
PMID: 38224350
Objective: The immunogenic nature of coronavirus disease 2019 (COVID-19) mRNA vaccines led to some initial concern that these could stimulate the HIV reservoir. We analyzed changes in plasma HIV loads...
3.
Shahid A, MacLennan S, Jones B, Sudderuddin H, Dang Z, Cobarrubias K, et al.
J Virol
. 2024 Jan;
98(2):e0165523.
PMID: 38214547
Within-host HIV populations continually diversify during untreated infection, and this diversity persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better understanding of on-ART proviral evolutionary dynamics, and...
4.
Kinloch N, Shahid A, Dong W, Kirkby D, Jones B, Beelen C, et al.
mBio
. 2023 Nov;
14(6):e0241723.
PMID: 37971267
Characterizing the human immunodeficiency virus (HIV) reservoir that endures despite antiretroviral therapy (ART) is critical to cure efforts. We observed that the oldest proviruses persisting during ART were exclusively defective,...
5.
Duncan M, Omondi F, Kinloch N, Lapointe H, Speckmaier S, Moran-Garcia N, et al.
medRxiv
. 2023 Oct;
PMID: 37873490
Objective: The immunogenic nature of COVID-19 mRNA vaccines led to some initial concern that these could stimulate the HIV reservoir. We analyzed changes in plasma HIV loads (pVL) and reservoir...
6.
Shahid A, MacLennan S, Jones B, Sudderuddin H, Dang Z, Cobamibias K, et al.
Res Sq
. 2023 Aug;
PMID: 37645749
Within-host HIV populations continually diversify during untreated infection, and members of these diverse forms persist within infected cell reservoirs, even during antiretroviral therapy (ART). Characterizing the diverse viral sequences that...
7.
Kinloch N, Shahid A, Dong W, Kirkby D, Jones B, Beelen C, et al.
bioRxiv
. 2023 Apr;
PMID: 37090500
In order to cure HIV, we need to better understand the within-host evolutionary origins of the small reservoir of genome-intact proviruses that persists within infected cells during antiretroviral therapy (ART)....
8.
Rosas-Umbert M, Gunst J, Pahus M, Olesen R, Schleimann M, Denton P, et al.
Nat Commun
. 2022 Oct;
13(1):6473.
PMID: 36309514
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To determine whether this phenomenon also occurs in humans we...
9.
Gunst J, Pahus M, Rosas-Umbert M, Lu I, Benfield T, Nielsen H, et al.
Nat Med
. 2022 Oct;
28(11):2424-2435.
PMID: 36253609
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial...
10.
Omondi F, Sudderuddin H, Shahid A, Kinloch N, Jones B, Miller R, et al.
mBio
. 2021 Nov;
12(6):e0249021.
PMID: 34781741
Curing HIV will require eliminating the reservoir of integrated, replication-competent proviruses that persist despite antiretroviral therapy (ART). Understanding the burden, genetic diversity, and longevity of persisting proviruses in diverse individuals...