Natalia Saldivia
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Explore the profile of Natalia Saldivia including associated specialties, affiliations and a list of published articles.
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10
Citations
60
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Recent Articles
1.
Saldivia N, Heller G, Zelada D, Whitehair J, Venkat N, Konjeti A, et al.
Mol Ther
. 2024 Jun;
32(9):3163-3176.
PMID: 38937968
Galactosyl-ceramidase (GALC) is a ubiquitous lysosomal enzyme crucial for the correct myelination of the mammalian nervous system during early postnatal development. However, the physiological consequence of GALC deficiency in the...
2.
Saldivia N, Salazar K, Cifuentes M, Espinoza F, Harrison F, Nualart F
Glia
. 2024 Jan;
72(4):708-727.
PMID: 38180226
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth,...
3.
Nualart F, Cifuentes M, Ramirez E, Martinez F, Barahona M, Ferrada L, et al.
PLoS Biol
. 2023 Sep;
21(9):e3002308.
PMID: 37733692
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ependymal cell ciliary beating to...
4.
Salazar K, Espinoza F, Cerda-Gallardo G, Ferrada L, Magdalena R, Ramirez E, et al.
Antioxidants (Basel)
. 2021 Sep;
10(9).
PMID: 34573045
During brain development, sodium-vitamin C transporter (SVCT2) has been detected primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex neuroblasts. However, strong SVCT2 expression is observed...
5.
Baeza V, Cifuentes M, Martinez F, Ramirez E, Nualart F, Ferrada L, et al.
Sci Rep
. 2021 Sep;
11(1):18537.
PMID: 34535732
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of...
6.
Espinoza F, Magdalena R, Saldivia N, Jara N, Martinez F, Ferrada L, et al.
Antioxidants (Basel)
. 2020 Dec;
9(12).
PMID: 33327638
The reduced form of vitamin C, ascorbic acid (AA), has been related with gene expression and cell differentiation in the cerebral cortex. In neurons, AA is mainly oxidized to dehydroascorbic...
7.
Ulloa V, Saldivia N, Ferrada L, Salazar K, Martinez F, Silva-Alvarez C, et al.
Sci Rep
. 2019 Oct;
9(1):14422.
PMID: 31594969
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the...
8.
Salazar K, Martinez F, Perez-Martin M, Cifuentes M, Trigueros L, Ferrada L, et al.
Mol Neurobiol
. 2017 Sep;
55(7):5439-5452.
PMID: 28942474
Ascorbic acid (AA), the reduced form of vitamin C, acts as a neuroprotector by eliminating free radicals in the brain. Sodium/vitamin C co-transporter isoform 2 (SVCT2) mediates uptake of AA...
9.
Stanic K, Saldivia N, Forstera B, Torrejon M, Montecinos H, Caprile T
Front Neuroanat
. 2016 Oct;
10:89.
PMID: 27733818
Extracellular matrix (ECM) molecules are pivotal for central nervous system (CNS) development, facilitating cell migration, axonal growth, myelination, dendritic spine formation, and synaptic plasticity, among other processes. During axon guidance,...
10.
Vera A, Recabal A, Saldivia N, Stanic K, Torrejon M, Montecinos H, et al.
Front Neuroanat
. 2015 Jun;
9:72.
PMID: 26074785
During early stages of development, encephalic vesicles are composed by a layer of neuroepithelial cells surrounding a central cavity filled with embryonic cerebrospinal fluid (eCSF). This fluid contains several morphogens...