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» Authors » Natalia Rusetska

Natalia Rusetska

Explore the profile of Natalia Rusetska including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 27
Citations 199
Followers 0
Related Specialties
Biochemistry
Oncology
Molecular Biology
Top 10 Co-Authors
Mateusz Bujko
Paulina Kober
Jacek Kunicki
Maria Maksymowicz
Janusz A Siedlecki
Joanna Boresowicz
Grzegorz Zielinski
Elzbieta Sarnowska
Monika Pekul
Artur Kowalik
Published In
Cancers (Basel)
Int J Mol Sci
Front Endocrinol (Lausanne)
J Clin Med
Pituitary
Affiliations
Soon will be listed here.
Recent Articles
1.
MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model
Bebenek W, Gajek A, Marczak A, Maly J, Smejkal J, Statkiewicz M, et al.
Int J Mol Sci . 2025 Jan; 26(2. PMID: 39859548
Hepatocellular carcinoma (HCC) cells critically depend on PARP1 and CHK1 activation for survival. Combining the PARP inhibitor (PARPi) olaparib with a CHK1 inhibitor (MK-8776, CHK1i) produced a synergistic effect, reducing...
2.
Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2 ovarian cancer models
Biegala L, Statkiewicz M, Gajek A, Szymczak-Pajor I, Rusetska N, Sliwinska A, et al.
Biochim Biophys Acta Mol Basis Dis . 2024 Nov; 1871(2):167574. PMID: 39557132
Resistance to olaparib inevitably develops in ovarian cancer (OC) patients, highlighting the necessity for effective strategies to improve its efficacy. Here, we established a novel olaparib-resistant patient-derived xenograft model of...
3.
Relevance of mutations in protein deubiquitinases genes and in corticotroph pituitary tumors
Pekul M, Szczepaniak M, Kober P, Rusetska N, Mossakowska B, Baluszek S, et al.
Front Endocrinol (Lausanne) . 2024 Mar; 15:1302667. PMID: 38487343
Introduction: Corticotroph pituitary neuroendocrine tumors (PitNETs) develop from ACTH-producing cells. They commonly cause Cushing's disease (CD), however, some remain clinically silent. Recurrent , , and mutations occur in corticotroph PitNETs....
4.
Epigenetic Downregulation of Hsa-miR-193b-3p Increases Cyclin D1 Expression Level and Cell Proliferation in Human Meningiomas
Kober P, Mossakowska B, Rusetska N, Baluszek S, Grecka E, Konopinski R, et al.
Int J Mol Sci . 2023 Sep; 24(17). PMID: 37686289
Meningiomas are common intracranial tumors in adults. Abnormal microRNA (miRNA) expression plays a role in their pathogenesis. Change in miRNA expression level can be caused by impaired epigenetic regulation of...
5.
DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment
Baluszek S, Kober P, Rusetska N, Wagrodzki M, Mandat T, Kunicki J, et al.
Acta Neuropathol Commun . 2023 Jul; 11(1):113. PMID: 37434245
Chordomas are rare tumors of notochord remnants, occurring mainly in the sacrum and skull base. Despite of their unusually slow growth, chordomas are highly invasive and the involvement of adjacent...
6.
The expression of glucocorticoid and mineralocorticoid receptors in pituitary tumors causing Cushing's disease and silent corticotroph tumors
Kober P, Rusetska N, Mossakowska B, Maksymowicz M, Pekul M, Zielinski G, et al.
Front Endocrinol (Lausanne) . 2023 Apr; 14:1124646. PMID: 37065760
Objective: Pituitary neuroendocrine corticotroph tumors commonly cause Cushing's disease (CD) that results from increased adrenocorticotropic hormone (ACTH) secretion by the pituitary tumor and consequent increase of cortisol levels in blood....
7.
Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly
Rymuza J, Kober P, Rusetska N, Mossakowska B, Maksymowicz M, Nyc A, et al.
Cells . 2022 Dec; 11(23). PMID: 36497102
Acromegaly results from growth hormone hypersecretion, predominantly caused by a somatotroph pituitary neuroendocrine tumor (PitNET). Acromegaly-causing tumors are histologically diverse. Our aim was to determine transcriptomic profiles of various somatotroph...
8.
The Expression of Cell Cycle-Related Genes in -Mutated Corticotroph Neuroendocrine Pituitary Tumors and Their Possible Role in Cell Cycle-Targeting Treatment
Mossakowska B, Rusetska N, Konopinski R, Kober P, Maksymowicz M, Pekul M, et al.
Cancers (Basel) . 2022 Nov; 14(22). PMID: 36428684
Protein deubiquitinases and are known driver genes in corticotroph pituitary neuroendocrine tumors (PitNETs). mutations have pleiotropic effects that include notable changes in genes' expression. Genes involved in cell cycle regulation...
9.
Difference in miRNA Expression in Functioning and Silent Corticotroph Pituitary Adenomas Indicates the Role of miRNA in the Regulation of Corticosteroid Receptors
Mossakowska B, Kober P, Rusetska N, Boresowicz J, Maksymowicz M, Pekul M, et al.
Int J Mol Sci . 2022 Mar; 23(5). PMID: 35270010
Corticotroph pituitary adenomas commonly cause Cushing's disease (CD), but some of them are clinically silent. The reason why they do not cause endocrinological symptoms remains unclear. We used data from...
10.
gene expression depends on BAF180 subunit of SWISNF chromatin remodeling complex and correlates with abundance of tumor infiltrating lymphocytes in ccRCC
Szarkowska J, Cwiek P, Szymanski M, Rusetska N, Jancewicz I, Stachowiak M, et al.
Am J Cancer Res . 2022 Jan; 11(12):5965-5978. PMID: 35018236
About 40% of clear cell renal cell carcinoma (ccRCC) cases carry the mutation inactivating BAF180 subunit of the SWI/SNF chromatin remodeling complex (CRC). Here we show that the majority of...