Natalia Rukoyatkina
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Explore the profile of Natalia Rukoyatkina including associated specialties, affiliations and a list of published articles.
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18
Citations
187
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Recent Articles
1.
Balykina A, Naida L, Kirkgoz K, Nikolaev V, Fock E, Belyakov M, et al.
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38732081
Flavonoid aglycones are secondary plant metabolites that exhibit a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antiplatelet effects. However, the precise molecular mechanisms underlying their inhibitory effect...
2.
Fock E, Pronin N, Rukoyatkina N, Whaley A, Gambaryan S, Whaley A
Nat Prod Res
. 2024 Apr;
:1-9.
PMID: 38567701
In this study, we expanded our previous work by testing compounds for their ability to inhibit platelet activation at low (30 µM) concentration by inhibition of ROS production, thromboxane synthase...
3.
Whaley A, Whaley A, Toporkova V, Fock E, Rukoyatkina N, Smirnov S, et al.
Fitoterapia
. 2023 Oct;
171:105697.
PMID: 37797794
Two previously undescribed isoquinoline alkaloids, bracteatinine (1) and isogroenlandicine (2), together with four known alkaloids - coptisine (3), dehydrocorydaline (4), palmatine (5) and jatrorrhizine (6) were isolated from the aerial...
4.
Breitenbach T, Englert N, Osmanoglu O, Rukoyatkina N, Wangorsch G, Heinze K, et al.
J Theor Biol
. 2022 Jul;
550:111222.
PMID: 35843440
Background: The cyclic nucleotides cAMP and cGMP inhibit platelet activation. Different platelet signaling modules work together. We develop here a modelling framework to integrate different signaling modules and apply it...
5.
Whaley A, Ponkratova A, Rukoyatkina N, Prilepskaya A, Bogoutdinova A, Fock E, et al.
Planta Med
. 2022 Jun;
PMID: 35688458
One new compound isoembinin 1 along with ten known compounds 2-11 were isolated from the terrestrial parts of Iris lactea Pall. All of the compound structures were determined through extensive...
6.
Shpakova V, Rukoyatkina N, Al Arawe N, Prilepskaya A, Kharazova A, Sharina I, et al.
J Pharmacol Exp Ther
. 2022 Feb;
381(2):164-175.
PMID: 35197320
12-lipoxigenase (12-LOX) is implicated in regulation of platelet activation processes and can be a new promising target for antiplatelet therapy. However, investigations of 12-LOX were restricted by the lack of...
7.
Shpakova V, Rukoyatkina N, Walter U, Gambaryan S
Platelets
. 2021 Nov;
33(6):859-868.
PMID: 34845961
Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors...
8.
Rukoyatkina N, Shpakova V, Bogoutdinova A, Kharazova A, Mindukshev I, Gambaryan S
Biochem Biophys Res Commun
. 2021 Nov;
586:20-26.
PMID: 34823218
Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known,...
9.
Rukoyatkina N, Shpakova V, Sudnitsyna J, Panteleev M, Makhoul S, Gambaryan S, et al.
Int J Mol Sci
. 2021 Jun;
22(10).
PMID: 34065600
Curcumin is a natural bioactive component derived from the turmeric plant , which exhibits a range of beneficial activities on human cells. Previously, an inhibitory effect of curcumin on platelets...
10.
Rukoyatkina N, Shpakova V, Panteleev M, Kharazova A, Gambaryan S, Geiger J
Thromb Res
. 2018 Sep;
171:22-30.
PMID: 30240944
Introduction: Arachidonic acid induced aggregation is a generally accepted test for aspirin resistance. However, doubts have been raised that arachidonic acid stimulated aggregation can be regarded as reliable testing for...