Nashaat Turkman
Overview
Explore the profile of Nashaat Turkman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
101
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Huang C, Khan P, Xu S, Cohen J, Georgakis G, Turkman N
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 38999983
The synthesis, biochemical evaluation and radiosynthesis of a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor and radioligand was performed. NT431, a newly synthesized 4-fluorobenzyl-abemaciclib, exhibited high potency to CDK4/6 and...
2.
Xu S, Huang C, Eyermann C, Georgakis G, Turkman N
Sci Rep
. 2024 Jul;
14(1):15100.
PMID: 38956204
The design and radiosynthesis of [F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [F]NT376...
3.
Turkman N, Xu S, Huang C, Eyermann C, Salino J, Khan P
J Med Chem
. 2023 Apr;
66(8):5611-5621.
PMID: 37068265
We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an...
4.
Li K, Wang M, Akoglu M, Pollard A, Klecker J, Alfonso P, et al.
ACS Pharmacol Transl Sci
. 2023 Mar;
6(3):410-421.
PMID: 36926452
Bruton's tyrosine kinase (BTK) is a target for treating B-cell malignancies and autoimmune diseases. To aid in the discovery and development of BTK inhibitors and improve clinical diagnoses, we have...
5.
Liu D, Cohen J, Turkman N
Sci Rep
. 2022 Jun;
12(1):10564.
PMID: 35732704
Given our interest in the utility of liposomes for molecular imaging and theranostics, we investigated how coating the outer layer of the liposome affects internalization by breast cancer cell lines...
6.
Turkman N, Liu D, Pirola I
Eur J Med Chem
. 2021 Dec;
228:114011.
PMID: 34875522
Herein, we describe the design, synthesis and deciphering of the key characteristics of the structure activity relationship (SAR) of trifluoromethyloxadiazole (TFMO) bearing class-IIa HDAC inhibitors. Our medicinal chemistry campaign of...
7.
Turkman N, Liu D, Pirola I
Sci Rep
. 2021 May;
11(1):10668.
PMID: 34021207
Small molecules that contain the (TFMO) moiety were reported to specifically inhibit the class-IIa histone deacetylases (HDACs), an important target in cancer and the disorders of the central nervous system...
8.
Li Y, Daryaee F, Yoon G, Noh D, Smith-Jones P, Si Y, et al.
ACS Infect Dis
. 2020 Jul;
6(8):2249-2259.
PMID: 32672928
Deep-seated bacterial infections caused by pathogens such as are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron...
9.
Bonomi R, Popov V, Laws M, Gelovani D, Majhi A, Shavrin A, et al.
J Med Chem
. 2018 Jul;
61(16):7116-7130.
PMID: 30052441
Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases....
10.
Bonomi R, Laws M, Popov V, Kamal S, Potukutchi S, Shavrin A, et al.
Mol Imaging Biol
. 2018 Feb;
20(4):594-604.
PMID: 29423902
Purpose: The purpose of this study was to develop a SIRT2-specific substrate-type radiotracer for non-invasive PET imaging of epigenetic regulatory processes mediated by SIRT2 in normal and disease tissues. Procedures:...