Naoki Sakai
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Explore the profile of Naoki Sakai including associated specialties, affiliations and a list of published articles.
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Articles
98
Citations
832
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Recent Articles
1.
Aoki R, Kumagawa E, Kamata K, Ago H, Sakai N, Hasunuma T, et al.
Commun Chem
. 2025 Jan;
8(1):17.
PMID: 39838140
Cyclic lipopeptides (CLPs) produced by the genus Bacillus are amphiphiles composed of hydrophilic amino acid and hydrophobic fatty acid moieties and are biosynthesised by non-ribosomal peptide synthetases (NRPSs). CLPs are...
2.
Dileep K, Sakai N, Ihara K, Nakata A, Ito A, Sivaraman D, et al.
Int J Biol Macromol
. 2024 Dec;
293:139320.
PMID: 39740711
The formation of the pyroglutamate variant of amyloid beta (pGlu-Aβ), which is extremely hydrophobic, rapidly aggregating, and highly neurotoxic, is mediated by the action of secretory glutaminyl cyclase (sQC). The...
3.
Koseki A, Suzuki Y, Uchida S, Morishita N, Hokazono Y, Kuriki K, et al.
Cureus
. 2024 Aug;
16(7):e64358.
PMID: 39131025
Primary central nervous system vasculitis (PCNSV) is an angiitis localized to the central nervous system (CNS), with various manifestations and no specific biomarkers. Herein, we report a case of PCNSV...
4.
Waki T, Imaizumi R, Uno K, Doi Y, Tsunashima M, Yamada S, et al.
Biochem Biophys Res Commun
. 2024 May;
718:150080.
PMID: 38735137
Catalytic promiscuity of enzymes plays a pivotal role in driving the evolution of plant specialized metabolism. Chalcone synthase (CHS) catalyzes the production of 2',4,4',6'-tetrahydroxychalcone (THC), a common precursor of plant...
5.
Sumi Y, Kim B, Ogure T, Kodama M, Sakai N, Kobayashi M
Sensors (Basel)
. 2024 May;
24(9).
PMID: 38732818
This study comprehensively investigates how rain and drizzle affect the object-detection performance of non-contact safety sensors, which are essential for the operation of unmanned aerial vehicles and ground vehicles in...
6.
Imaizumi R, Matsuura H, Yanai T, Takeshita K, Misawa S, Yamaguchi H, et al.
Chembiochem
. 2024 Jan;
25(7):e202300796.
PMID: 38225831
Neryl diphosphate (C) synthase (NDPS1), a homodimeric soluble cis-prenyltransferase from tomato, contains four disulfide bonds, including two inter-subunit S-S bonds in the N-terminal region. Mutagenesis studies demonstrated that the S-S...
7.
Okuma H, Saijo-Hamano Y, Yamada H, Sherif A, Hashizaki E, Sakai N, et al.
Genes Cells
. 2023 Nov;
29(1):17-38.
PMID: 37984375
Irgb6 is a priming immune-related GTPase (IRG) that counteracts Toxoplasma gondii. It is known to be recruited to the low virulent type II T. gondii parasitophorous vacuole (PV), initiating cell-autonomous...
8.
Matsuura H, Sakai N, Toma-Fukai S, Muraki N, Hayama K, Kamikubo H, et al.
Acta Crystallogr D Struct Biol
. 2023 Sep;
79(Pt 10):909-924.
PMID: 37747037
In macromolecular structure determination using X-ray diffraction from multiple crystals, the presence of different structures (structural polymorphs) necessitates the classification of the diffraction data for appropriate structural analysis. Hierarchical clustering...
9.
Maeta S, Nakakido M, Matsuura H, Sakai N, Hirata K, Kuroda D, et al.
Protein Sci
. 2023 Aug;
32(9):e4745.
PMID: 37550885
Antibodies are used for many therapeutic and biotechnological purposes. Because the affinity of an antibody to the antigen is critical for clinical efficacy of pharmaceuticals, many affinity maturation strategies have...
10.
Yanai T, Takahashi Y, Katsumura E, Sakai N, Takeshita K, Imaizumi R, et al.
J Biochem
. 2023 Jun;
174(4):335-344.
PMID: 37384427
The sesaminol triglucoside (STG)-hydrolyzing β-glucosidase from Paenibacillus sp. (PSTG1), which belongs to glycoside hydrolase family 3 (GH3), is a promising catalyst for the industrial production of sesaminol. We determined the...