Naoaki Morihara
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Explore the profile of Naoaki Morihara including associated specialties, affiliations and a list of published articles.
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24
Citations
330
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Recent Articles
1.
Miki S, Suzuki J, Kunimura K, Morihara N
Exp Ther Med
. 2020 Feb;
19(2):1462-1467.
PMID: 32010323
AMP-activated protein kinase (AMPK) is an ubiquitously expressed serine/threonine kinase and an important regulator of energy metabolism. The decreased activity of AMPK induced by low-grade chronic inflammation has been implicated...
2.
Maeda T, Miki S, Morihara N, Kagawa Y
Exp Ther Med
. 2019 Jul;
18(1):857-866.
PMID: 31281460
Aged garlic extract (AGE) produced by the aging process has various beneficial pharmacological effects. In this study, the effects of AGE on fatty liver, insulin resistance and intestinal microbiota were...
3.
Tsuneyoshi T, Kunimura K, Morihara N
Nitric Oxide
. 2019 Jan;
84:22-29.
PMID: 30630055
Garlic has been demonstrated to exert protective effects against oxidative damage using numerous experimental models. The antioxidant effects of garlic are associated with the activation of Nrf2-dependent gene expression. S-1-Propenylcysteine...
4.
Suzuki J, Kodera Y, Miki S, Ushijima M, Takashima M, Matsutomo T, et al.
Sci Rep
. 2018 Sep;
8(1):14148.
PMID: 30237533
The degradation of target proteins by small molecules utilizing the cellular proteolytic system is featured as a treatment strategy of several diseases. We found that S-1-propenylcysteine (S1PC) among several cysteine...
5.
Ushijima M, Takashima M, Kunimura K, Kodera Y, Morihara N, Tamura K
J Pharm Pharmacol
. 2018 Jan;
70(4):559-565.
PMID: 29380376
Objectives: This study was designed to investigate the antihypertensive effect of S-1-propenylcysteine, a characteristic sulfur compound in aged garlic extract, using a hypertensive rat model. Methods: The blood pressure and...
6.
Morihara N, Hino A, Miki S, Takashima M, Suzuki J
Mol Nutr Food Res
. 2017 Jul;
61(10).
PMID: 28726277
Scope: Chronic inflammation plays a major role in the formation and progression of atherosclerotic plaques. To clarify the mode of action of aged garlic extract (AGE) to retard atherosclerosis, we...
7.
Matsutomo T, Ushijima M, Kodera Y, Nakamoto M, Takashima M, Morihara N, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2017 Feb;
1046:147-155.
PMID: 28183044
Aged garlic extract (AGE) has been shown to improve hypertension in both clinical trials and experimental animal models. However, the active ingredient of AGE remains unknown. In the present study,...
8.
Takashima M, Kanamori Y, Kodera Y, Morihara N, Tamura K
Phytomedicine
. 2017 Feb;
24:56-61.
PMID: 28160862
Background: Clinical trials have shown that aged garlic extract (AGE) is effective in reducing blood pressure of hypertensive patients. However, the mechanisms involved remain to be elucidated. Purpose: The aim...
9.
Miki S, Inokuma K, Takashima M, Nishida M, Sasaki Y, Ushijima M, et al.
Mol Nutr Food Res
. 2017 Jan;
61(5).
PMID: 28074608
Scope: In this study, we investigated the effect of aged garlic extract (AGE) on the high level of blood glucose in Tsumura Suzuki Obese-Diabetes (TSOD) mice. Methods And Results: TSOD...
10.
Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets
Morihara N, Hino A
J Nat Med
. 2016 Oct;
71(1):249-256.
PMID: 27766480
Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the...