Nao-Aki Watanabe
Overview
Explore the profile of Nao-Aki Watanabe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
473
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tawaraishi T, Ochida A, Akao Y, Itono S, Kamaura M, Akther T, et al.
J Med Chem
. 2023 Jan;
66(2):1221-1238.
PMID: 36607408
Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against , the causative agent of...
2.
Akao Y, Canan S, Cao Y, Condroski K, Engkvist O, Itono S, et al.
RSC Med Chem
. 2021 May;
12(3):384-393.
PMID: 34041487
An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-]pyridine screening hit for visceral leishmaniasis. probing of five proprietary pharmaceutical company libraries enabled rapid expansion...
3.
Van Voorhis W, Adams J, Adelfio R, Ahyong V, Akabas M, Alano P, et al.
PLoS Pathog
. 2016 Jul;
12(7):e1005763.
PMID: 27467575
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is...
4.
Watanabe N, Miyazaki M, Horii T, Sagane K, Tsukahara K, Hata K
Antimicrob Agents Chemother
. 2011 Dec;
56(2):960-71.
PMID: 22143530
Continued research toward the development of new antifungals that act via inhibition of glycosylphosphatidylinositol (GPI) biosynthesis led to the design of E1210. In this study, we assessed the selectivity of...
5.
Miyazaki M, Horii T, Hata K, Watanabe N, Nakamoto K, Tanaka K, et al.
Antimicrob Agents Chemother
. 2011 Aug;
55(10):4652-8.
PMID: 21825291
E1210 is a new antifungal compound with a novel mechanism of action and broad spectrum of antifungal activity. We investigated the in vitro antifungal activities of E1210 compared to those...
6.
Hata K, Horii T, Miyazaki M, Watanabe N, Okubo M, Sonoda J, et al.
Antimicrob Agents Chemother
. 2011 Jul;
55(10):4543-51.
PMID: 21788462
E1210 is a first-in-class, broad-spectrum antifungal with a novel mechanism of action-inhibition of fungal glycosylphosphatidylinositol biosynthesis. In this study, the efficacies of E1210 and reference antifungals were evaluated in murine...
7.
Tsukahara K, Hata K, Nakamoto K, Sagane K, Watanabe N, Kuromitsu J, et al.
Mol Microbiol
. 2003 May;
48(4):1029-42.
PMID: 12753194
Glycosylphosphatidylinositol (GPI)-anchored cell wall mannoproteins are required for the adhesion of pathogenic fungi, such as Candida albicans, to human epithelium. Small molecular inhibitors of the cell surface presentation of GPI-anchored...