Alpha 2.0
Login Register
» Authors » Nanthakumar Thirunarayanan

Nanthakumar Thirunarayanan

Explore the profile of Nanthakumar Thirunarayanan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 223
Followers 0
Related Specialties
Gastroenterology
General Medicine
Oncology
Top 10 Co-Authors
Lloyd Mayer
Sergio A Lira
Glaucia C Furtado
Gerold Bongers
Noam Harpaz
David Maussang
Limin Shang
Andrea P Martin
Marvin C Gershengorn
Luciana R Muniz
Published In
Gastroenterology
Neuropsychopharmacology
J Clin Invest
Oncotarget
Front Endocrinol (Lausanne)
Affiliations
Soon will be listed here.
Recent Articles
1.
MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR
Krause C, Popp O, Thirunarayanan N, Dittmar G, Lipp M, Muller G
Oncotarget . 2016 Feb; 7(9):10414-32. PMID: 26871287
The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded chemokine receptor vGPCR acts as an oncogene in Kaposi's sarcomagenesis. Until now, the molecular mechanisms by which the vGPCR contributes to tumor development remain incompletely...
2.
Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice
Thirunarayanan N, Nir E, Raaka B, Gershengorn M
Neuropsychopharmacology . 2013 Jan; 38(6):950-6. PMID: 23303050
Thyrotropin-releasing hormone receptor type 2 (TRH-R2), not TRH-R1, has been proposed to mediate the CNS effects of TRH and its more effective analog taltirelin (TAL). Consistent with this idea, TAL...
3.
Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor
Thirunarayanan N, Raaka B, Gershengorn M
Front Endocrinol (Lausanne) . 2012 Oct; 3:120. PMID: 23087672
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human...
4.
A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans
Bongers G, Muniz L, Pacer M, Iuga A, Thirunarayanan N, Slinger E, et al.
Gastroenterology . 2012 May; 143(3):730-740. PMID: 22643351
Background & Aims: Epithelial cancers can be initiated by activating mutations in components of the mitogen-activated protein kinase signaling pathway such as v-raf murine sarcoma viral oncogene homolog B1 (BRAF),...
5.
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice
Bongers G, Maussang D, Muniz L, Noriega V, Fraile-Ramos A, Barker N, et al.
J Clin Invest . 2010 Oct; 120(11):3969-78. PMID: 20978345
US28 is a constitutively active chemokine receptor encoded by CMV (also referred to as human herpesvirus 5), a highly prevalent human virus that infects a broad spectrum of cells, including...
6.
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine
Shang L, Thirunarayanan N, Viejo-Borbolla A, Martin A, Bogunovic M, Marchesi F, et al.
Gastroenterology . 2009 Jun; 137(3):1006-18, 1018.e1-3. PMID: 19501588
Background & Aims: Chemokines are small proteins that direct leukocyte trafficking under homeostatic and inflammatory conditions. We analyzed the differential expression of chemokines in distinct segments of the intestine and...
7.
Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
Shang L, Fukata M, Thirunarayanan N, Martin A, Arnaboldi P, Maussang D, et al.
Gastroenterology . 2008 Jun; 135(2):529-38. PMID: 18522803
Background & Aims: Several lines of evidence support a role for Toll-like receptor (TLR) signaling to protect the intestine from pathogenic infection. We hypothesized that TLR signaling at the level...