Nalinie S Wickramasinghe
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Explore the profile of Nalinie S Wickramasinghe including associated specialties, affiliations and a list of published articles.
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12
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Recent Articles
1.
Malovichko M, Abplanalp W, McFall S, Taylor B, Wickramasinghe N, Sithu I, et al.
Toxicol Appl Pharmacol
. 2021 Oct;
431:115742.
PMID: 34624356
Benzene is a ubiquitous environmental pollutant. Recent population-based studies suggest that benzene exposure is associated with an increased risk for cardiovascular disease. However, it is unclear whether benzene exposure by...
2.
Abplanalp W, Wickramasinghe N, Sithu S, Conklin D, Xie Z, Bhatnagar A, et al.
Toxicol Sci
. 2018 Oct;
167(2):426-437.
PMID: 30346588
Benzene is a ubiquitous pollutant associated with hematotoxicity but its metabolic effects are unknown. We sought to determine if and how exposure to volatile benzene impacted glucose handling. We exposed...
3.
Sithu S, Malovichko M, Riggs K, Wickramasinghe N, Winner M, Agarwal A, et al.
JCI Insight
. 2017 May;
2(9).
PMID: 28469073
Mechanisms of atherogenesis have been studied extensively in genetically engineered mice with disturbed cholesterol metabolism such as those lacking either the LDL receptor (Ldlr) or apolipoprotein E (apoe). Few other...
4.
Vladykovskaya E, Sithu S, Haberzettl P, Wickramasinghe N, Merchant M, Hill B, et al.
J Biol Chem
. 2012 Jan;
287(14):11398-409.
PMID: 22228760
Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial activation, and they increase the adhesion of the endothelium to circulating leukocytes. Nevertheless, the mechanisms underlying these effects remain unclear. We...
5.
Klinge C, Riggs K, Wickramasinghe N, Emberts C, McConda D, Barry P, et al.
Mol Cell Endocrinol
. 2010 Mar;
323(2):268-76.
PMID: 20302909
Resistance to endocrine therapy is a major clinical problem in breast cancer. The role of ERalpha splice variants in endocrine resistance is largely unknown. We observed reduced protein expression of...
6.
Schultz D, Wickramasinghe N, Ivanova M, Isaacs S, Dougherty S, Imbert-Fernandez Y, et al.
Mol Cancer Ther
. 2010 Mar;
9(3):594-605.
PMID: 20197399
Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid) is a dietary and medicinal phytochemical with established anticancer activity in cell and animal models. The mechanisms by which AnAc inhibits cancer cell proliferation remain...
7.
Wickramasinghe N, Manavalan T, Dougherty S, Riggs K, Li Y, Klinge C
Nucleic Acids Res
. 2009 Mar;
37(8):2584-95.
PMID: 19264808
Select changes in microRNA (miRNA) expression correlate with estrogen receptor alpha (ER alpha) expression in breast tumors. miR-21 is higher in ER alpha positive than negative tumors, but no one...
8.
Klinge C, Wickramasinghe N, Ivanova M, Dougherty S
FASEB J
. 2008 Feb;
22(7):2185-97.
PMID: 18296501
Epidemiological studies correlate moderate red wine consumption to reduced incidence of cardiovascular disease. Resveratrol is a polyphenolic compound in red wine that has cardioprotective effects in rodents. Although endothelial cell...
9.
Mattingly K, Ivanova M, Riggs K, Wickramasinghe N, Barch M, Klinge C
Mol Endocrinol
. 2007 Dec;
22(3):609-22.
PMID: 18048642
Estrogen has direct and indirect effects on mitochondrial activity, but the mechanisms mediating these effects remain unclear. Others reported that long-term estradiol (E(2)) treatment increased nuclear respiratory factor-1 (NRF-1) protein...
10.
Riggs K, Wickramasinghe N, Cochrum R, Watts M, Klinge C
Cancer Res
. 2006 Oct;
66(20):10188-98.
PMID: 17047084
Tamoxifen (TAM) is successfully used for the treatment and prevention of breast cancer. However, many patients that are initially TAM responsive develop tumors that are antiestrogen/TAM resistant (TAM-R). The mechanism...