Naina Phadnis
Overview
Explore the profile of Naina Phadnis including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
251
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0
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Recent Articles
1.
Phadnis N, Cipak L, Polakova S, Hyppa R, Cipakova I, Anrather D, et al.
PLoS Genet
. 2015 May;
11(5):e1005225.
PMID: 25993311
Proper meiotic chromosome segregation, essential for sexual reproduction, requires timely formation and removal of sister chromatid cohesion and crossing-over between homologs. Early in meiosis cohesins hold sisters together and also...
2.
Kalifa L, Quintana D, Schiraldi L, Phadnis N, Coles G, Sia R, et al.
Genetics
. 2012 Jan;
190(3):951-64.
PMID: 22214610
Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences;...
3.
Phadnis N, Hyppa R, Smith G
Trends Genet
. 2011 Jul;
27(10):411-21.
PMID: 21782271
The unique segregation of homologs, rather than sister chromatids, at the first meiotic division requires the formation of crossovers (COs) between homologs by meiotic recombination in most species. Crossovers do...
4.
Ellermeier C, Higuchi E, Phadnis N, Holm L, Geelhood J, Thon G, et al.
Proc Natl Acad Sci U S A
. 2010 Apr;
107(19):8701-5.
PMID: 20421495
During meiosis, the formation of viable haploid gametes from diploid precursors requires that each homologous chromosome pair be properly segregated to produce an exact haploid set of chromosomes. Genetic recombination,...
5.
Kalifa L, Beutner G, Phadnis N, Sheu S, Sia E
DNA Repair (Amst)
. 2009 Aug;
8(10):1242-9.
PMID: 19699691
Although the nuclear processes responsible for genomic DNA replication and repair are well characterized, the pathways involved in mitochondrial DNA (mtDNA) replication and repair remain unclear. DNA repair has been...
6.
Phadnis N, Mehta R, Meednu N, Sia E
DNA Repair (Amst)
. 2006 May;
5(7):829-39.
PMID: 16730479
Mitochondrial DNA is predicted to be highly prone to oxidative damage due to its proximity to free radicals generated by oxidative phosphorylation. Base excision repair (BER) is the primary repair...
7.
Phadnis N, Sia R, Sia E
Genetics
. 2005 Sep;
171(4):1549-59.
PMID: 16157666
Mitochondrial DNA deletions and point mutations accumulate in an age-dependent manner in mammals. The mitochondrial genome in aging humans often displays a 4977-bp deletion flanked by short direct repeats. Additionally,...
8.
Phadnis N, Ayres Sia E
J Mol Biol
. 2004 Sep;
342(4):1115-29.
PMID: 15351639
The nuclear gene MIP1 encodes the mitochondrial DNA polymerase responsible for replicating the mitochondrial genome in Saccharomyces cerevisiae. A number of other factors involved in replicating and segregating the mitochondrial...