Nadine Obier
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Explore the profile of Nadine Obier including associated specialties, affiliations and a list of published articles.
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19
Citations
436
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Recent Articles
1.
Maytum A, Obier N, Cauchy P, Bonifer C
Front Epigenet Epigenom
. 2024 Nov;
2.
PMID: 39506987
The ability of cells to respond to external stimuli is one of the characteristics of life as we know it. Multicellular organisms have developed a huge machinery that interprets the...
2.
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, et al.
Nat Commun
. 2023 Nov;
14(1):6947.
PMID: 37935654
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements...
3.
Zhang Y, Velasco-Hernandez T, Mess J, Lalioti M, Romero-Mulero M, Obier N, et al.
Blood Adv
. 2023 Aug;
7(24):7525-7538.
PMID: 37639313
Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells (HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of HSC dormancy. However,...
4.
Schuster E, Epple M, Glaser K, Mihlan M, Lucht K, Zimmermann J, et al.
Nat Metab
. 2022 Jul;
4(7):856-866.
PMID: 35864246
Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify...
5.
Zhang Y, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero M, et al.
Nat Cell Biol
. 2022 Jun;
24(7):1038-1048.
PMID: 35725769
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by...
6.
Schonberger K, Obier N, Romero-Mulero M, Cauchy P, Mess J, Pavlovich P, et al.
Cell Stem Cell
. 2021 Oct;
29(1):131-148.e10.
PMID: 34706256
Hematopoietic stem cells (HSCs) rely on complex regulatory networks to preserve stemness. Due to the scarcity of HSCs, technical challenges have limited our insights into the interplay between metabolites, transcription,...
7.
Clapes T, Polyzou A, Prater P, Sagar , Morales-Hernandez A, Galvao Ferrarini M, et al.
Nat Cell Biol
. 2021 Oct;
23(12):1338.
PMID: 34611323
No abstract available.
8.
Clapes T, Polyzou A, Prater P, Sagar , Morales-Hernandez A, Galvao Ferrarini M, et al.
Nat Cell Biol
. 2021 Jul;
23(7):704-717.
PMID: 34253898
Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by...
9.
Vijayabaskar M, Goode D, Obier N, Lichtinger M, Emmett A, Zainul Abidin F, et al.
PLoS Comput Biol
. 2019 Nov;
15(11):e1007337.
PMID: 31682597
Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these...
10.
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, et al.
Nat Struct Mol Biol
. 2019 May;
26(5):361-371.
PMID: 31061526
Histone lysine methylation is generally performed by SET domain methyltransferases and regulates chromatin structure and gene expression. Here, we identify human C21orf127 (HEMK2, N6AMT1, PrmC), a member of the seven-β-strand...