Nabil J Alkayed
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Explore the profile of Nabil J Alkayed including associated specialties, affiliations and a list of published articles.
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124
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2872
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Recent Articles
21.
Martini R, Siler D, Cetas J, Alkayed N, Allen E, Treggiari M
Neurocrit Care
. 2021 Dec;
36(3):905-915.
PMID: 34873674
Background: Epoxyeicosatrienoates (EETs) are endogenous regulators of neuroinflammation and cerebral blood flow. Their metabolism to dihydroxyeicosatrienoates (DHETs) is catalyzed by soluble epoxide hydrolase (sEH). After subarachnoid hemorrhage (SAH), EETs' pathway...
22.
Davis C, Bah T, Zhang W, Nelson J, Golgotiu K, Nie X, et al.
Alzheimers Dement (N Y)
. 2021 Oct;
7(1):e12214.
PMID: 34692987
Introduction: The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G-protein coupled receptor, is implicated in neurological disorders but its role in VCI is unknown....
23.
Emechebe U, Giraud D, Ammi A, Scott K, Jacobs J, McDermott J, et al.
Data Brief
. 2021 Sep;
38:107343.
PMID: 34527795
Cardiac endothelial cells respond to both ischemia and therapeutic ultrasound; the proteomic changes underlying these responses are unknown. This data article provides raw and processed data resulting from our global,...
24.
Schenning K, Holden S, Davis B, Mulford A, Nevonen K, Quinn J, et al.
J Alzheimers Dis
. 2021 Aug;
83(3):1251-1268.
PMID: 34420963
Background: Geriatric surgical patients are at higher risk of developing postoperative neurocognitive disorders (NCD) than younger patients. The specific mechanisms underlying postoperative NCD remain unknown, but they have been linked...
25.
Xu Y, Barnes A, Alkayed N
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360964
GPR39, a member of the ghrelin family of G protein-coupled receptors, is zinc-responsive and contributes to the regulation of diverse neurovascular and neurologic functions. Accumulating evidence suggests a role as...
26.
Nagarajan S, Qian Z, Marimuthu P, Alkayed N, Kaul S, Barnes A
J Chem Inf Model
. 2021 Jul;
61(7):3442-3452.
PMID: 34242503
G-protein coupled receptors (GPCRs) sense a wide variety of stimuli, including lipids, and transduce signals to the intracellular environment to exert various physiological responses. However, the structural features of GPCRs...
27.
Emechebe U, Giraud D, Ammi A, Scott K, Jacobs J, McDermott J, et al.
Biochim Biophys Acta Proteins Proteom
. 2021 Jun;
1869(9):140683.
PMID: 34119693
Myocardial infarction and subsequent therapeutic interventions activate numerous intracellular cascades in every constituent cell type of the heart. Endothelial cells produce several protective compounds in response to therapeutic ultrasound, under...
28.
Emechebe U, Nelson J, Alkayed N, Kaul S, Adey A, Barnes A
Physiol Genomics
. 2021 Jun;
53(7):295-308.
PMID: 34097533
Aging is a significant risk factor for cardiovascular disease. Despite the fact that endothelial cells play critical roles in cardiovascular function and disease, the molecular impact of aging on this...
29.
30.
Davis C, Zhang W, Allen E, Bah T, Shangraw R, Alkayed N
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34063817
Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic...