Nabeel B Nabulsi
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Explore the profile of Nabeel B Nabulsi including associated specialties, affiliations and a list of published articles.
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31
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1197
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Recent Articles
1.
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, et al.
Biol Psychiatry
. 2024 Oct;
97(6):651-658.
PMID: 39395473
Background: Dopaminergic tone and phasic release have transdiagnostic relevance. Preclinical research suggests that the active form of vitamin D, calcitriol, increases subcortical tyrosine hydroxylase, D/D receptors, and amphetamine-stimulated dopamine release...
2.
Salardini E, ODell R, Tchorz E, Nabulsi N, Huang Y, Carson R, et al.
bioRxiv
. 2024 Oct;
PMID: 39386453
Background: The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer's disease (AD). Positron emission...
3.
Young J, ODell R, Naganawa M, Toyonaga T, Chen M, Nabulsi N, et al.
J Nucl Med
. 2024 Sep;
65(11):1782-1785.
PMID: 39299782
Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method...
4.
Naganawa M, Gallezot J, Li S, Nabulsi N, Henry S, Cai Z, et al.
Eur J Nucl Med Mol Imaging
. 2024 Aug;
52(1):113-121.
PMID: 39155309
Purpose: [F]SynVesT-1, a positron emission tomography (PET) radiotracer for the synaptic vesicle glycoprotein 2A (SV2A), demonstrates kinetics similar to [C]UCB-J, with high brain uptake, fast kinetics fitting well with the...
5.
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, et al.
Eur J Nucl Med Mol Imaging
. 2023 Nov;
51(4):1012-1022.
PMID: 37955791
Purpose: Aging is a major societal concern due to age-related functional losses. Synapses are crucial components of neural circuits, and synaptic density could be a sensitive biomarker to evaluate brain...
6.
Silva-Rudberg J, Salardini E, ODell R, Chen M, Ra J, Georgelos J, et al.
Am J Geriatr Psychiatry
. 2023 Sep;
32(1):17-28.
PMID: 37673749
Objective: Multimodal imaging techniques have furthered our understanding of how different aspects of Alzheimer's disease (AD) pathology relate to one another. Diffusion tensor imaging (DTI) measures such as mean diffusivity...
7.
ODell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, et al.
Neuroimage Clin
. 2023 Jul;
39:103457.
PMID: 37422964
Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer's disease (AD). We used principal component analysis (PCA) to identify regional patterns...
8.
Naganawa M, Gallezot J, Finnema S, Maguire R, Mercier J, Nabulsi N, et al.
EJNMMI Res
. 2022 Nov;
12(1):71.
PMID: 36346513
Background: Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed...
9.
Mecca A, ODell R, Sharp E, Banks E, Bartlett H, Zhao W, et al.
Alzheimers Dement
. 2022 Feb;
18(12):2527-2536.
PMID: 35174954
Introduction: For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD). However, this statement is based on remarkably few...
10.
Mecca A, Chen M, ODell R, Naganawa M, Toyonaga T, Godek T, et al.
Neurobiol Aging
. 2021 Dec;
111:44-53.
PMID: 34963063
Sites of early neuropathologic change provide important clues regarding the initial clinical features of Alzheimer's disease (AD). We have shown significant reductions in hippocampal synaptic density in participants with AD,...