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N Weich

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Articles 15
Citations 230
Followers 0
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Recent Articles
1.
Ferri C, Weich N, Gutierrez L, De Brasi C, Bengio M, Zapata P, et al.
Gene . 2019 Feb; 694:71-75. PMID: 30738963
The BCR-ABL1 oncogene is associated with chronic myeloid leukemia (CML) pathogenesis, but the molecular mechanisms that initiate leukemogenesis are still unclear. Cancer pathogenesis has been associated with genetic alterations that...
2.
Weich N, Nunez M, Galimberti G, Elena G, Acevedo S, Larripa I, et al.
Hematology . 2015 Mar; 20(9):511-6. PMID: 25799091
Background And Aim: Despite recent major advances in leukemia research, the etiopathogenesis of childhood leukemias remains far elusive. Individual predisposing factors, including polymorphisms in detoxification enzymes, have been implicated in...
3.
Lindenthal C, Weich N, Chia Y, Heussler V, Klinkert M
Parasitology . 2005 Jul; 131(Pt 1):37-44. PMID: 16038394
Protein degradation is regulated during the cell cycle of all eukaryotic cells and is mediated by the ubiquitin-proteasome pathway. Potent and specific peptide-derived inhibitors of the 20S proteasome have been...
4.
Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, et al.
Biochem J . 2001 Sep; 359(Pt 1):109-18. PMID: 11563974
Myelopoiesis and lymphopoiesis are controlled by haematopoietic growth factors, including cytokines, and chemokines that bind to G-protein-coupled receptors (GPCRs). Regulators of G-protein signalling (RGSs) are a protein family that can...
5.
Lu L, Wang L, Cooper R, Liu H, Turner K, Weich N, et al.
J Hematother Stem Cell Res . 2000 May; 9(2):195-204. PMID: 10813532
CD34+ cells from human umbilical cord blood (CB) were isolated and investigated for megakaryocytic (MK) colony formation in response to recombinant human (rh) stimulatory and suppressive cytokines and compared with...
6.
Morris J, Neben S, Bennett F, Finnerty H, Long A, Beier D, et al.
Exp Hematol . 1996 Oct; 24(12):1369-76. PMID: 8913282
Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated...
7.
Turner K, Neben S, Weich N, Schaub R, Goldman S
Stem Cells . 1996 Jan; 14 Suppl 1:53-61. PMID: 11012203
Recombinant human interleukin 11 (rHuIL-11) is a multifunctional cytokine with activities on a broad range of hematopoietic cells including primitive stem cells and mature progenitor cells. Analysis of rHuIL-11 in...
8.
Lu L, Xiao M, Li Z, Jolliffe L, Jones S, Broxmeyer H, et al.
Exp Hematol . 1995 Sep; 23(10):1130-4. PMID: 7656932
Human interleukin-3/erythropoietin (IL-3/Epo) fusion protein have been constructed, expressed, and tested for biological activity. These fusion proteins were previously shown to be active on erythroid progenitors (BFU-E) from unseparated human...
9.
Bernad A, Kopf M, Kulbacki R, Weich N, Koehler G, Gutierrez-Ramos J
Immunity . 1994 Dec; 1(9):725-31. PMID: 7895162
The development of blood cells from hematopoietic stem cells is controlled by multiple cytokines. These growth factors influence survival, cell cycle status, differentiation into lineage-committed progenitors, final maturation into blood...
10.
Carroll M, Spivak J, McMahon M, Weich N, Rapp U, May W
J Biol Chem . 1991 Aug; 266(23):14964-9. PMID: 1869534
Erythropoietin mediates the rapid phosphorylation of Raf-1 in the murine cell lines HCD-57 and FDC-P1/ER, which proliferate in response to this cytokine. Phosphorylation occurs at both serine and tyrosine residues...