N Sitaram
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Explore the profile of N Sitaram including associated specialties, affiliations and a list of published articles.
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80
Citations
784
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Recent Articles
1.
Sitaram N
Curr Med Chem
. 2006 Mar;
13(6):679-96.
PMID: 16529559
Antimicrobial peptides, which constitute an important component of innate immunity in animal and plant kingdom, are ubiquitously distributed in nature. However, they differ widely in their sizes, sequences and structures....
2.
Sitaram N, Nagaraj R
Curr Drug Targets
. 2002 Jun;
3(3):259-67.
PMID: 12041739
Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they...
3.
Sitaram N, Nagaraj R
Curr Pharm Des
. 2002 Apr;
8(9):727-42.
PMID: 11945168
Antimicrobial peptides are important components of innate immunity in species across the evolutionary scale. Unlike therapeutically used antibiotics, this class of peptides exert their activity by permeabilizing bacterial membranes. Despite...
4.
Subbalakshmi C, Nagaraj R, Sitaram N
J Pept Res
. 2001 Feb;
57(1):59-67.
PMID: 11168889
The biological activities of synthetic retro and diastereo analogs of PKLLKTFLSKWIG (SPFK), a 13-residue peptide with antimicrobial and hemolytic activities, have been investigated. Retro peptides with C-terminal acid and amide...
5.
Sai K, Jagannadham M, Vairamani M, Raju N, DEVI A, Nagaraj R, et al.
J Biol Chem
. 2000 Oct;
276(4):2701-7.
PMID: 11031261
Four broad-spectrum, 11 and 12 residue, novel antimicrobial peptides have been isolated from the adrenaline-stimulated skin secretions of the Indian frog Rana tigerina. Sequences of these peptides have been determined...
6.
Subbalakshmi C, Bikshapathy E, Sitaram N, Nagaraj R
Biochem Biophys Res Commun
. 2000 Aug;
274(3):714-6.
PMID: 10924341
The structure and biological activities of analogs of the bovine neutrophil antibacterial and hemolytic peptide indolicidin, ILPWKWPWWPWRR-amide, where one tryptophan at 4th, 8th, or 11th position has been retained and...
7.
Krishnakumari V, Sharadadevi A, Sitaram N, Nagaraj R
J Pept Res
. 1999 Dec;
54(6):528-35.
PMID: 10604598
The effect of introducing a disulfide bridge between the N- and C-terminal ends on the structure and biological activities of the 13-residue linear peptide PKLLKTFLSKWIG(SPFK), which has both antibacterial and...
8.
Sitaram N, Nagaraj R
Biochim Biophys Acta
. 1999 Dec;
1462(1-2):29-54.
PMID: 10590301
Species right across the evolutionary scale from insects to mammals use peptides as part of their host-defense system to counter microbial infection. The primary structures of a large number of...
9.
Subbalakshmi C, Nagaraj R, Sitaram N
FEBS Lett
. 1999 Apr;
448(1):62-6.
PMID: 10217411
Melittin, the 26-residue predominant toxic peptide from bee venom, exhibits potent antibacterial activity in addition to its hemolytic activity. The synthetic peptide of 15 residues corresponding to its C-terminal end...
10.
Bikshapathy E, Sitaram N, Nagaraj R
J Pept Res
. 1999 Apr;
53(1):47-55.
PMID: 10195441
The consequences of selective addition or deletion of polar amino acids in a 13-residue antibacterial peptide PKLLKTFLSKWIG on structure, membrane binding and biological activities have been investigated. The variants generated...