N Shaun B Thomas
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Explore the profile of N Shaun B Thomas including associated specialties, affiliations and a list of published articles.
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25
Citations
634
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Recent Articles
1.
Chung S, Ng J, Laddach A, Thomas N, Fraternali F
NAR Genom Bioinform
. 2021 Mar;
3(1):lqab010.
PMID: 33709075
Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein-protein interactions (PPIs). Here, we establish an pipeline to identify specific...
2.
Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, et al.
Blood
. 2016 Jun;
128(9):1193-205.
PMID: 27281795
Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T cells (Tregs)...
3.
Marson C, Matthews C, Atkinson S, Lamadema N, Thomas N
J Med Chem
. 2015 Aug;
58(17):6803-18.
PMID: 26287310
A novel series of potent chiral inhibitors of histone deacetylase (HDAC) is described that contains an oxazoline capping group and a N-(2-aminophenyl)-benzamide unit. Among several new inhibitors of this type...
4.
Chung S, Pandini A, Annibale A, Coolen A, Thomas N, Fraternali F
Sci Rep
. 2015 Feb;
5:8540.
PMID: 25703051
Protein-protein interaction networks (PPINs) have been employed to identify potential novel interconnections between proteins as well as crucial cellular functions. In this study we identify fundamental principles of PPIN topologies...
5.
Thomas N
JAKSTAT
. 2013 Sep;
1(4):257-60.
PMID: 24058781
Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al.(1) showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data...
6.
Marson C, Matthews C, Yiannaki E, Atkinson S, Soden P, Shukla L, et al.
J Med Chem
. 2013 Jul;
56(15):6156-74.
PMID: 23829483
The synthesis of a novel series of potent chiral inhibitors of histone deacetylase (HDAC) is described that contain a heterocyclic capping group and a N-(2-aminophenyl)benzamide unit that binds in the...
7.
Hamilton E, Pearce L, Morgan L, Robinson S, Ware V, Brennan P, et al.
Br J Haematol
. 2012 Jun;
158(5):589-99.
PMID: 22712573
Interactions in the tumour microenvironment can promote chronic lymphocytic leukaemia (CLL) cell survival, proliferation and drug resistance. A detailed comparison of three co-culture systems designed to mimic the CLL lymph...
8.
Orr S, Boutz D, Wang R, Chronis C, Lea N, Thayaparan T, et al.
Mol Syst Biol
. 2012 Mar;
8:573.
PMID: 22415777
Regulating the transition of cells such as T lymphocytes from quiescence (G(0)) into an activated, proliferating state involves initiation of cellular programs resulting in entry into the cell cycle (proliferation),...
9.
Gaken J, Mohamedali A, Jiang J, Malik F, Stangl D, Smith A, et al.
Nucleic Acids Res
. 2012 Feb;
40(10):e75.
PMID: 22323518
MicroRNAs (miRNA) are a class of small RNA molecules that regulate numerous critical cellular processes and bind to partially complementary sequences resulting in down-regulation of their target genes. Due to...
10.
Carlin L, Evans R, Milewicz H, Fernandes L, Matthews D, Perani M, et al.
Sci Signal
. 2011 Dec;
4(201):ra81.
PMID: 22126964
Natural killer (NK) cells kill tumor cells and virally infected cells, and an effective NK cell response requires processes, such as motility, recognition, and directional secretion, that rely on cytoskeletal...