N R Hackett
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Explore the profile of N R Hackett including associated specialties, affiliations and a list of published articles.
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55
Citations
2035
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Recent Articles
1.
Krause A, Whu W, Qiu J, Wafadari D, Hackett N, Sharma A, et al.
Clin Exp Immunol
. 2013 Apr;
173(2):230-41.
PMID: 23607394
Replication-deficient adenoviral (Ad) vectors of non-human serotypes can serve as Ad vaccine platforms to circumvent pre-existing anti-human Ad immunity. We found previously that, in addition to that feature, a non-human...
2.
Dyke J, Sondhi D, Voss H, Shungu D, Mao X, Yohay K, et al.
AJNR Am J Neuroradiol
. 2012 Oct;
34(4):884-9.
PMID: 23042927
Background And Purpose: LINCL is a uniformly fatal lysosomal storage disease resulting from mutations in the CLN2 gene that encodes for tripeptidyl peptidase 1, a lysosomal enzyme necessary for the...
3.
Butler M, Hackett N, Salit J, Strulovici-Barel Y, Omberg L, Mezey J, et al.
Eur Respir J
. 2011 Feb;
38(1):15-28.
PMID: 21349909
The glutathione S-transferase (GST) enzymes catalyse the conjugation of xenobiotics to glutathione. Based on reports that inherited copy number variations (CNVs) modulate some GST gene expression levels, and that the...
4.
Wang G, Qiu J, Wang R, Krause A, Boyer J, Hackett N, et al.
Cancer Gene Ther
. 2010 May;
17(8):559-70.
PMID: 20448672
Trastuzumab (Herceptin) is a recombinant humanized monoclonal antibody (mAb) directed against an extracellular region of the human epidermal growth-factor receptor type 2 (HER2) protein. We hypothesized that a single adeno-associated...
5.
Dyke J, Voss H, Sondhi D, Hackett N, Worgall S, Heier L, et al.
AJNR Am J Neuroradiol
. 2007 Aug;
28(7):1232-6.
PMID: 17698521
Background And Purpose: Late infantile neuronal ceroid lipofuscinosis (LINCL), a form of Batten disease, is a fatal neurodegenerative genetic disorder, diagnosed via DNA testing, that affects approximately 200 children in...
6.
Worgall S, Kekatpure M, Heier L, Ballon D, Dyke J, Shungu D, et al.
Neurology
. 2007 Aug;
69(6):521-35.
PMID: 17679671
Background: Late infantile neuronal ceroid lipofuscinosis (LINCL) is associated with progressive degeneration of the brain and retina starting in early childhood. Methods: Thirty-two individual neurologic, ophthalmologic, and CNS imaging (MRI...
7.
Sondhi D, Peterson D, Giannaris E, Sanders C, Mendez B, De B, et al.
Gene Ther
. 2005 Jul;
12(22):1618-32.
PMID: 16052206
Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal, autosomal recessive disease resulting from mutations in the CLN2 gene with consequent deficiency in its product tripeptidyl peptidase I (TPP-I). In...
8.
Kianmanesh A, Hackett N, Lee J, Kikuchi T, Korst R, Crystal R
Hum Gene Ther
. 2001 Dec;
12(17):2035-49.
PMID: 11747595
Although tumor necrosis factor alpha (TNF-alpha) is a potent cytokine with a myriad of innate immune antitumor properties, systemic administration of TNF-alpha is associated with significant toxicity, limiting the use...
9.
Sondhi D, Hackett N, Apblett R, Kaminsky S, Pergolizzi R, Crystal R
Arch Neurol
. 2001 Nov;
58(11):1793-8.
PMID: 11708986
Late infantile neuronal ceroid lipofuscinosis is a progressive childhood neurodegenerative disorder characterized by intracellular accumulation of autofluorescent material resembling lipofuscin in neuronal cells. This report summarizes the new therapies under...
10.
Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, et al.
Nat Med
. 2001 Nov;
7(11):1194-201.
PMID: 11689883
The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known. We demonstrate here that tumor angiogenesis is associated with recruitment of hematopoietic and circulating endothelial precursor...